The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin-induced diabetic rats

被引：9

作者：

Wei, Qi ^{[1
]}

Huang, Linxiang ^{[1
]}

Li, Jie ^{[1
]}

Chen, Bingzhi ^{[1
]}

Xie, Baogui ^{[2
]}

Teng, Hui ^{[1
]}

Chen, Lei ^{[1
]}

Jiang, Yuji ^{[1
]}

机构：

[1] Fujian Agr & Forestry Univ, Coll Food Sci, Fuzhou 350002, Fujian, Peoples R China

[2] Fujian Agr & Forestry Univ, Mycol Res Ctr, Fuzhou, Fujian, Peoples R China

来源：

JOURNAL OF FOOD BIOCHEMISTRY | 2020年 / 44卷 / 05期

关键词：

Agaricus blazei Murrill; antioxidant activity; diabetes mellitus; immunohistochemistry; oxidative stress; streptozotocin; MEDICINAL MUSHROOM; OXIDATIVE STRESS; BLAZEI; PATHOGENESIS; DYSFUNCTION; PREVENTION; CULTURE; LIVER; MICE;

D O I：

10.1111/jfbc.13170

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Agaricus blazei Murrill (ABM), is a medicinal mushroom, has beneficial effects on diabetes mellitus. In this study, ABM extracts (ethanol extract, EE and ethyl acetate extract, EA) were evaluated to explore the beneficial effect on hepatic antioxidant activity and recovery of the pancreatic tissue in streptozotocin-induced diabetic rats. The hepatic antioxidant activities of ABM extracts were analyzed by superoxide dismutase, catalase activity, glutathione, aspartate transaminase, and alanine transaminase. Moreover, the effects of ABM extracts on pancreatic tissue restoration were investigated by histopathological analysis. The results revealed that the EA showed a better protective effect on hepatic antioxidant activity and recovery of the impaired pancreatic tissues, compared to EE. The results suggested that ABM treatment could effectively reduce oxidative stress and contribute to pancreatic tissue recovery. Therefore, ABM could be used as a functional food to control diabetes. Practical applications The research may contribute to the development of ABM as functional foods or dietary supplements for diabetes in the future.

引用

页数：10

共 36 条

[1]

Abugri D. A., 2013, Journal of Natural Product and Plant Resources, V3, P37

[2] Effect of Lactarius piperatus fruiting body maturity stage on antioxidant activity measured by several biochemical assays [J].

Barros, Lillian ;

Baptista, Paula ;

Ferreira, Isabel C. F. R. .

FOOD AND CHEMICAL TOXICOLOGY, 2007, 45 (09) :1731-1737

[3] Mitochondrial dysfunction and complications associated with diabetes [J].

Blake, Rachel ;

Trounce, Ian A. .

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 2014, 1840 (04) :1404-1412

[4] Marked Expansion of Exocrine and Endocrine Pancreas With Incretin Therapy in Humans With Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-Producing Neuroendocrine Tumors [J].

Butler, Alexandra E. ;

Campbell-Thompson, Martha ;

Gurlo, Tatyana ;

Dawson, David W. ;

Atkinson, Mark ;

Butler, Peter C. .

DIABETES, 2013, 62 (07) :2595-2604

[5] Bioactives of fruiting bodies and submerged culture mycelia of Agaricus brasiliensis (A. blazei) and their antioxidant properties [J].

Carvajal, Anne Elise S. S. ;

Koehnlein, Eloa A. ;

Soares, Andreia A. ;

Eler, Gabrieli J. ;

Nakashima, Alika T. A. ;

Bracht, Adelar ;

Peralta, Rosane M. .

LWT-FOOD SCIENCE AND TECHNOLOGY, 2012, 46 (02) :493-499

[6] MONOCLONAL-ANTIBODIES AGAINST RECOMBINANT PARTS OF THE KI-67 ANTIGEN (MIB-1 AND MIB-3) DETECT PROLIFERATING CELLS IN MICROWAVE-PROCESSED FORMALIN-FIXED PARAFFIN SECTIONS [J].

CATTORETTI, G ;

BECKER, MHG ;

KEY, G ;

DUCHROW, M ;

SCHLUTER, C ;

GALLE, J ;

GERDES, J .

JOURNAL OF PATHOLOGY, 1992, 168 (04) :357-363

[7] Intracellular signaling pathways of inflammation modulated by dietary flavonoids: The most recent evidence [J].

Chen, Lei ;

Teng, Hui ;

Jia, Zhen ;

Battino, Maurizio ;

Miron, Anca ;

Yu, Zhiling ;

Cao, Hui ;

Xiao, Jianbo .

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION, 2018, 58 (17) :2908-2924

[8] Agrimonolide from Agrimonia pilosa suppresses inflammatory responses through down-regulation of COX-2/iNOS and inactivation of NF-κB in lipopolysaccharide-stimulated macrophages [J].

Chen, Lei ;

Teng, Hui ;

Fang, Ting ;

Xiao, Jianbo .

PHYTOMEDICINE, 2016, 23 (08) :846-855

[9] Study of anti-inflammatory activity of Tibetan mushroom, a symbiotic culture of bacteria and fungi encapsulated into a polysaccharide matrix [J].

Diniz, RO ;

Garla, LK ;

Schneedorf, JM ;

Carvalho, JCT .

PHARMACOLOGICAL RESEARCH, 2003, 47 (01) :49-52

[10] Type 2 diabetes as an inflammatory disease [J].

Donath, Marc Y. ;

Shoelson, Steven E. .

NATURE REVIEWS IMMUNOLOGY, 2011, 11 (02) :98-107

← 1 2 3 4 →