Aim: This study aimed to explore the effect of active nursing for liver cancer patients complicated with obstructive jaundice after intervention therapy. Methods: A total of 80 liver cancer patients complicated with obstructive jaundice who were treated in our hospital were selected as research subjects, and divided into a study group and a control group according to the different intervention nursing methods (40 patients in each group). The control group patients were given routine nursing intervention, while the study group patients were given active additional nursing measures in addition to the routine nursing given to the control group. In the end, this research compared the postoperative recovery, liver function, quality of life, immune index and the complication rate of these two groups. Results: After operation, the study group patients had less time before they were able to get out of bed, shorter extubation period, and quicker discharge than study group patients (P<0.05); additionally, on the 3rd day and 7th day after intervention, the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the study group were significantly lower than that in the control group (P<0.05). In both groups, pain and quality of life had a good trend after operation, yet the improvement in study group was more obvious than that in control group (P<0.05); in immune index comparison, the CD4+ and CD8+ levesl in study group also showed greater improvement than that in control group (P<0.05), and the incidence of postoperative complications in study group was apparently lower than that in control group (P<0.05). Conclusion: Active postoperative nursing care is conducive to accelerating the recovery of patients, improving postoperative immunity and liver function, and reducing the incidence of various complications in liver cancer patients complicated with obstructive jaundice, and hence is recommended for clinical application.