Pathophysiology of bronchial smooth muscle remodelling in asthma

被引：125
|
作者：
Bara, I. [1 ,2 ]
Ozier, A. [1 ,2 ,3 ]
de Lara, J-M Tunon [1 ,2 ,3 ]
Marthan, R. [1 ,2 ,3 ]
Berger, P. [1 ,2 ,3 ]
机构：
[1] Univ Bordeaux, UB2, Lab Physiol Cellulaire Resp, Bordeaux, France
[2] INSERM, U885, Bordeaux, France
[3] CHU Bordeaux, Bordeaux, France
来源：
EUROPEAN RESPIRATORY JOURNAL | 2010年 / 36卷 / 05期
关键词：
Asthma; bronchi; proliferation; remodelling; smooth muscle; GROWTH-FACTOR-BETA; EXTRACELLULAR-MATRIX PROTEINS; BRONCHOALVEOLAR LAVAGE FLUID; EPITHELIAL-MESENCHYMAL TRANSITION; RETICULAR BASEMENT-MEMBRANE; MAST-CELL DEGRANULATION; AIR-FLOW OBSTRUCTION; GLUCOCORTICOID-RECEPTOR; CIRCULATING FIBROCYTES; INDUCED PROLIFERATION;
D O I：
10.1183/09031936.00019810
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Whereas the role of bronchial smooth muscle remains controversial in healthy subjects its role is well established in asthmatics. Bronchial smooth muscle contraction induces airway narrowing. The smooth muscle also contributes to bronchial inflammation by secreting a range of inflammatory mediators, recruiting and activating inflammatory cells, such as mast cells or T-lymphocytes. In addition, bronchial smooth muscle mass is significantly increased in asthma. Such an increase has been related to a deposition of extracellular matrix proteins, and an increase in both cell size and number. However, the mechanisms of this smooth muscle remodelling are complex and not completely understood. The article will review recent data regarding the pathophysiology of bronchial smooth muscle remodelling in asthma.
引用
收藏
页码：1174 / 1184
页数：11
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