Widespread theta coherence during spatial cognitive control

Cognitive control allows humans to process relevant sensory information while minimizing distractions from irrelevant stimuli. The neural basis of cognitive control is known to involve frontal regions of the brain such as the medial prefrontal cortex (mPFC) and anterior cingulate cortex (ACC), but the temporal dynamics of larger scale networks is unclear. Here we used EEG with source localization to identify how the neural oscillations localized to the mPFC and ACC coordinate with parietal, sensory, and motor areas during spatial cognitive control. Theta coherence (3-8 Hz) between the mPFC and ACC increased with task difficulty and predicted individual differences in reaction time. Individual differences in accuracy were predicted by earlier activation of ACC-motor coherence, highlighting the relationship between processing speed and task performance. Our results provide evidence that successful cognitive control requires dynamic coordination between a widespread network of brain regions. Long range theta coherence may be a key mechanism for efficient cognitive control across the neocortex.