Novel effect of sildenafil on hair growth

被引：18

作者：

Choi, Hye-In ^{[1
,2
]}

Kang, Bo-Mi ^{[1
,2
]}

Jang, Jeehee ^{[1
,2
]}

Hwang, Sungjoo Tommy ^{[3
]}

Kwon, Ohsang ^{[1
,2
,4
]}

机构：

[1] Seoul Natl Univ Hosp, Clin Res Inst, Lab Cutaneous Aging & Hair Res, Seoul, South Korea

[2] Seoul Natl Univ, Inst Human Environm Interface Biol, Coll Med, Seoul, South Korea

[3] Dr Hwangs Hair Hair Clin, Seoul, South Korea

[4] Seoul Natl Univ, Dept Dermatol, Coll Med, 101 Daehak Ro, Seoul 03080, South Korea

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 505卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Sildenafil; Phosphodiesterase; 5; inhibitor; Hair growth; Hair loss; TOPICAL MINOXIDIL; PULMONARY-HYPERTENSION; ERECTILE DYSFUNCTION; ALOPECIA-AREATA; ANGIOGENESIS; INDUCTION; PATHWAY; SKIN; INHIBITION; FOLLICLES;

D O I：

10.1016/j.bbrc.2018.09.164

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Sildenafil, a phosphodiesterase 5 (PDE5) inhibitor, is known to increase the intracellular level of cyclic guanosine monophosphate (cGMP), which causes vasodilation. However, the effect of sildenafil on human hair follicles (hHFs) is unknown. Objective: The purpose of this study was to determine the role of sildenafil in hair growth. Methods: We investigated the expression of PDE5 in human dermal papilla cells (hDPCs) and hHFs. The effects of sildenafil on hDPC proliferation were evaluated using BrdU assays. The mRNA expression of growth factors and extracellular signal-regulated kinase (ERK) phosphorylation were investigated using real-time PCR and western blotting, respectively. Additionally, anagen induction and perifollicular vessel formation were evaluated using an in vivo mice model. Results: We confirmed high expression of PDE5 in hDPCs and hHFs. Sildenafil enhances proliferation of hDPCs and up-regulates the mRNA expression of vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF), which are responsible for hair growth. Additionally, sildenafil up-regulates the levels of phosphorylated ERK and accelerates anagen induction by stimulating perifollicular vessel formation after topical application in mice. Conclusion: Our study demonstrates for the first time, the significant therapeutic potential of sildenafil on hair growth and its potential use in treatment of alopecia. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：685 / 691

页数：7

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