α-Cyclodextrin concentration-controlled thermo-sensitive supramolecular hydrogels

被引：47
作者：
Liu, Lin [1 ]
Feng, Xiangru [2 ]
Pei, Yueting [1 ]
Wang, Jinze [1 ]
Ding, Jianxun [2 ]
Chen, Li [1 ]
机构：
[1] Northeast Normal Univ, Dept Chem, Changchun 130024, Jilin, Peoples R China
[2] Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China
来源：
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2018年 / 82卷
基金：
中国国家自然科学基金;
关键词：
Thermo-sensitivity; Inclusion complex; Base-pairing interaction; Supramolecular hydrogel; Biomedical application; DRUG-DELIVERY; SUSTAINED-RELEASE; BETA-CYCLODEXTRIN; NUCLEOBASE; NANOCARRIERS; DOXORUBICIN; INCLUSION; COPOLYMER; GELS;
D O I：
10.1016/j.msec.2017.08.045
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Supramolecular hydrogels (SHGs) built from inclusion complex of macrocyclic compound alpha-cyclodextrin (alpha-CD) and poly(ethylene glycol) (PEG) have attracted much interest due to their excellent biocompatibility and great potential for biomedical applications. In this work, the hydrogen bond of nucleic acid was introduced into the above-mentioned SHG by syntheses of nucleobase guanine/cytosine (G/C)-terminated PEG (G-PEG-G/C-PEG-C). The base-pairing interaction between G and C as an additional network junction effectively enhanced storage moduli (Gs) of the hydrogels. Moreover, the prepared hydrogels exhibited excellent cytocompatibility and property for controlled drug release, outlining the potential of thermo-sensitive construct for biomedical applications, such as local chemotherapy of cancers.
引用
收藏
页码：25 / 28
页数：4
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