Copper(I)-catalyzed synthesis of 3,3-disubstituted isoindolin-1-ones from enamides via cascade radical addition and cyclization

被引：11
|
作者：
Yu, Hui [1 ]
Xuan, Pengfei [1 ]
Lin, Jingbo [1 ]
Jiao, Mingdong [1 ]
机构：
[1] Tongji Univ, Shanghai Key Lab Chem Assessment & Substainabil, Sch Chem Sci & Engn, 1239 Siping Rd, Shanghai 200092, Peoples R China
来源：
TETRAHEDRON LETTERS | 2018年 / 59卷 / 40期
关键词：
Copper(I)-catalyzed; Radical; Enamides; N-Alkyl isoindolin-1-ones; DTBP; Benzylation; C-H BOND; FORMYLMETHYL-SUBSTITUTED ENAMIDES; ACTIVATED ALKENES; TERTIARY ENAMIDES; HIGHLY EFFICIENT; OXINDOLES; ISOINDOLINONES; ACRYLAMIDES; DERIVATIVES; BENZAMIDES;
D O I：
10.1016/j.tetlet.2018.09.002
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Copper(I) catalyzed radical benzylation and cyclization reaction of tertiary enamides was investigated and 3,3-disubstituted N-Alkyl isoindolin-l-ones were obtained in moderate to good yields. In this reaction, two new C-C bonds were formed in one step with high atom economy. Possible reaction pathway for the formation of the products was also discussed in this paper. (C) 2018 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3636 / 3641
页数：6
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