Neuroprotective naphthalene and flavan derivatives from Polygonum cuspidatum

被引：26

作者：

Liu, Fu ^{[1
,2
]}

Li, Fu-shuang ^{[1
,2
]}

Feng, Zi-ming ^{[1
,2
]}

Yang, Ya-nan ^{[1
,2
]}

Jiang, Jian-shuang ^{[1
,2
]}

Li, Li ^{[1
,2
]}

Zhang, Pei-cheng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Bioact Substance & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China

[2] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

PHYTOCHEMISTRY | 2015年 / 110卷

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

Polygonum cuspidatum; Polygonaceae; Phenolic compounds; Neuroprotective effects; RESVERATROL OLIGOMERS; STILBENE GLYCOSIDE; OLIGOSTILBENES; INHIBITORS; ROOTS; ANTHRAQUINONE; GLUCOSIDES;

D O I：

10.1016/j.phytochem.2014.12.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ten naphthalene derivatives including two unusual glycosides possessing a naphthalene-fused piceid via a [C8'-O-C6-C5-C7']-trans-dihydrofuran ring, two flavan derivatives, as well as sixteen known phenolic compounds, were isolated from Polygonum cuspidatum. The structures were determined by extensive NMR, MS, CD data, and chemical evidence. In the in vitro neuroprotective assays, at the concentration of 10 mu M, five of these compounds exhibited significant effects against PC12 cells injured by rotenone. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：150 / 159

页数：10

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