The synthesis and determination of acidic ionization constants of certain 5-substituted 2-aminopyrrolo[2,3-d]pyrimidin-4-ones and methylated analogs

被引：12

作者：

Hoops, GC

Park, J

Garcia, GA

Townsend, LB

机构：

[1] Interdepartmental Grad. Prog. M., College of Pharmacy, University of Michigan, Ann Arbor

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1996年 / 33卷 / 03期

关键词：

D O I：

10.1002/jhet.5570330341

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The acidic ionization constants were determined for a series of 5-substituted 2-aminopyrrolo[2,3-dl-pyrimidin-4-ones and N-3- and N-7-methylated analogs thereof. The syntheses of the methylated analogs are also described.

引用

页码：767 / 781

页数：15

共 23 条

[1] SYNTHESIS OF QUEUINE, THE BASE OF NATURALLY-OCCURRING HYPERMODIFIED NUCLEOSIDE (QUEUOSINE), AND ITS ANALOGS
AKIMOTO, H
IMAMIYA, E
HITAKA, T
NOMURA, H
NISHIMURA, S
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1988, (07): : 1637 - 1644
[2] Albert A., 1984, DETERMINATION IONIZA
[3] REACTION OF 2-ACETAMIDO-3,7-DIHYDROPYRROLO[2,3-D]PYRIMIDIN-4-ONE WITH DIMETHYLAMINE AND FORMALDEHYDE - FORMATION OF 2 ISOMERIC MANNICH-BASES
BENGHIAT, E
CROOKS, PA
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1983, 20 (04) : 1023 - 1025
[4] PYRIMIDINE REACTIONS .4. METHYLATION OF 2,4- AND 4,5-DIAMINOPYRIMIDINE AND RELATED COMPOUNDS
BROWN, DJ
JACOBSEN, NW
[J]. JOURNAL OF THE CHEMICAL SOCIETY, 1962, (AUG): : 3172 - &
[5] THE USE OF C-13 MAGNETIC-RESONANCE CHEMICAL-SHIFTS AND LONG-RANGE C-13-H-1 COUPLING-CONSTANTS FOR ASSIGNING THE SITE OF GLYCOSYLATION ON NITROGEN-HETEROCYCLES
CLINE, BL
FAGERNESS, PE
PANZICA, RP
TOWNSEND, LB
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2, 1980, (11): : 1586 - 1591
[6] DAVOLL J, 1960, J CHEM SOC, V131
[7] TRANSFER-RNA-GUANINE TRANSGLYCOSYLASE FROM ESCHERICHIA-COLI - STRUCTURE-ACTIVITY STUDIES INVESTIGATING THE ROLE OF THE AMINOMETHYL SUBSTITUENT OF THE HETEROCYCLIC SUBSTRATE PREQ(1)
HOOPS, GC
TOWNSEND, LB
GARCIA, GA
[J]. BIOCHEMISTRY, 1995, 34 (46) : 15381 - 15387
[8] KONDO T, 1980, CHEM LETT, V559
[9] Levene P. A., 1926, J BIOL CHEM, V70, P229, DOI 10.1016/s0021-9258(18)84540-9
[10] STRUCTURE, BIOSYNTHESIS, AND FUNCTION OF QUEUOSINE IN TRANSFER-RNA
NISHIMURA, S
[J]. PROGRESS IN NUCLEIC ACID RESEARCH AND MOLECULAR BIOLOGY, 1983, 28 : 49 - 73

← 1 2 3 →