Transplantation of placenta-derived mesenchymal stem cell-induced neural stem cells to treat spinal cord injury

被引：26
|
作者：
Li, Zhi [1 ]
Zhao, Wei [1 ]
Liu, Wei [2 ]
Zhou, Ye [2 ]
Jia, Jingqiao [3 ]
Yang, Lifeng [1 ]
机构：
[1] Shenyang Med Coll, Affiliated Cent Hosp, Dept Orthoped, Shenyang 110024, Liaoning, Peoples R China
[2] Shenyang Med Coll, Affiliated Cent Hosp, Dept Obstet, Shenyang 110024, Liaoning, Peoples R China
[3] Liaoning Prov Wellcare Stem Cells Biotechnol Co L, Benxi, Liaoning, Peoples R China
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 24期
关键词：
nerve regeneration; stem cells; placenta-derived mesenchymal stem cells; spinal cord injury; neural stem cells; nerve-like cells; motor function; sensory function; neural regeneration; AMNIOTIC MEMBRANE; REPAIR;
D O I：
10.4103/1673-5374.147953
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Because of their strong proliferative capacity and multi-potency, placenta-derived mesenchymal stem cells have gained interest as a cell source in the field of nerve damage repair. In the present study, human placenta-derived mesenchymal stem cells were induced to differentiate into neural stem cells, which were then transplanted into the spinal cord after local spinal cord injury in rats. The motor functional recovery and pathological changes in the injured spinal cord were observed for 3 successive weeks. The results showed that human placenta-derived mesenchymal stem cells can differentiate into neuron-like cells and that induced neural stem cells contribute to the restoration of injured spinal cord without causing transplant rejection. Thus, these cells promote the recovery of motor and sensory functions in a rat model of spinal cord injury. Therefore, human placenta-derived mesenchymal stem cells may be useful as seed cells during the repair of spinal cord injury.
引用
收藏
页码：2197 / 2204
页数：8
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