Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy

被引：35

作者：

Adamus, Grazyna ^{[1
]}

Champaigne, Rachel ^{[1
]}

Yang, Sufang ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Sch Med, Casey Eye Inst, Ocular Immunol Lab, Portland, OR 97239 USA

来源：

CLINICAL IMMUNOLOGY | 2020年 / 210卷

基金：

美国国家卫生研究院;

关键词：

GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE; GLYCOLYTIC-ENZYMES; LUNG-CANCER; PROTEIN; RECOVERIN; PATIENT; ENOLASE;

D O I：

10.1016/j.clim.2019.108317

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoantibodies (AAbs) against retinal antigens can be found in patients with cancer and unexplained vision loss unrelated to the cancer metastasis. Cancer-associated retinopathy (CAR) is a rare paraneoplastic visual syndrome mediated by AAbs. Our goal was to determine whether CAR patients with different malignancies have a specific AAb or repertoire of AAbs that could serve as biomarkers for retinal disease. We found AAbs against 12 confirmed retinal antigens, with a-enolase being the most frequently recognized. The significant finding of the study was a high incidence of anti-aldolase AAbs in colon-CAR, anti-CAII in prostate-CAR, and anti-arrestin in skin melanoma patients thus these AAbs could serve as biomarkers in the context of clinical presentation and could support the diagnosis of CAR. However, a lack of AAb restriction to any one antigenic protein or to one retinal cellular location makes screening for a CAR biomarker challenging.

引用

页数：8

共 35 条

[1] Anti-enolase-α autoantibodies in cancer-associated retinopathy:: Epitope mapping and cytotoxicity on retinal cells [J].