Acute Stroke Patients Have Occult Malignancy More Often than Expected

被引:58
作者
Uemura, Jyunichi [1 ]
Kimura, Kazumi [1 ]
Sibazaki, Kensaku [1 ]
Inoue, Takeshi [1 ]
Iguchi, Yasuyuki [1 ]
Yamashita, Shinji [1 ]
机构
[1] Kawasaki Med Sch, Dept Stroke Med, Kurashiki, Okayama 7010192, Japan
关键词
Acute ischemic stroke; Occult malignancy; Nonbacterial thrombotic endocarditis; NONBACTERIAL THROMBOTIC ENDOCARDITIS; ANEMIC CANCER-PATIENTS; QUALITY-OF-LIFE; FACTOR-V-LEIDEN; D-DIMER; CEREBROVASCULAR COMPLICATIONS; ECHOCARDIOGRAPHIC FEATURES; HEMOGLOBIN LEVELS; ISCHEMIC-STROKE; FATIGUE;
D O I
10.1159/000316764
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The aim of the present study was to investigate the frequency of having occult malignancy in patients with acute ischemic stroke and their clinical characteristics. We retrospectively enrolled 1,714 consecutive ischemic stroke patients within 7 days of onset. The patients were divided into two groups: the Non-M group had no malignancy, and the M group had malignancy. We compared the clinical characteristics of the two groups. Of 1,714 ischemic stroke patients, 51 patients (3.0%; M group) were newly diagnosed as having malignancy. The M group was significantly older than the Non-M group (p = 0.009). Hemoglobin (Hb) was less and D-dimer was higher in the M group than in the Non-M group (p < 0.001). The patients with both D-dimer >= 1.3 ng/dl and Hb <12.8 g/dl more frequently had occult malignancy than patients without (p = 0.0088). Copyright (c) 2010 S. Karger AG, Basel
引用
收藏
页码:140 / 144
页数:5
相关论文
共 28 条
[1]   Plasma D-dimer levels in operable breast cancer patients correlate with clinical stage and axillary lymph node status [J].
Blackwell, K ;
Haroon, Z ;
Broadwater, G ;
Berry, D ;
Harris, L ;
Iglehart, JD ;
Dewhirst, M ;
Greenberg, C .
JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (03) :600-608
[2]  
BLANCHARD DG, 1981, CHEST, V70, P867
[3]   The longitudinal relationship of hemoglobin, fatigue and quality of life in anemic cancer patients: results from rive randomized clinical trials [J].
Cella, D ;
Kallich, J ;
McDermott, A ;
Xu, X .
ANNALS OF ONCOLOGY, 2004, 15 (06) :979-986
[4]   Stroke in patients with cancer - Incidence and etiology [J].
Cestari, DM ;
Weine, DM ;
Panageas, KS ;
Segal, AZ ;
DeAngelis, LM .
NEUROLOGY, 2004, 62 (11) :2025-2030
[5]   SHOULD CEREBRAL ISCHEMIC EVENTS IN CANCER-PATIENTS BE CONSIDERED A MANIFESTATION OF HYPERCOAGULABILITY [J].
CHATURVEDI, S ;
ANSELL, J ;
RECHT, L .
STROKE, 1994, 25 (06) :1215-1218
[6]   Fibrin fragment D-dimer and the risk of future venous thrombosis [J].
Cushman, M ;
Folsom, AR ;
Wang, L ;
Aleksic, N ;
Rosamond, WD ;
Tracy, RP ;
Heckbert, SR .
BLOOD, 2003, 101 (04) :1243-1248
[7]   Cardiac valvular vegetations in cancer patients: A prospective echocardiographic study of 200 patients [J].
Edoute, Y ;
Haim, N ;
Rinkevich, D ;
Brenner, B ;
Reisner, SA .
AMERICAN JOURNAL OF MEDICINE, 1997, 102 (03) :252-258
[8]   Improving the reliability of stroke subgroup classification using the Trial of ORG 10172 in Acute Stroke Treatment (TOAST) criteria [J].
Goldstein, LB ;
Jones, MR ;
Matchar, DB ;
Edwards, LJ ;
Hoff, J ;
Chilukuri, V ;
Armstrong, SB ;
Horner, RD .
STROKE, 2001, 32 (05) :1091-1096
[9]   CEREBROVASCULAR COMPLICATIONS IN PATIENTS WITH CANCER [J].
GRAUS, F ;
ROGERS, LR ;
POSNER, JB .
MEDICINE, 1985, 64 (01) :16-35
[10]  
Grogan M, 1999, CANCER-AM CANCER SOC, V86, P1528, DOI 10.1002/(SICI)1097-0142(19991015)86:8<1528::AID-CNCR20>3.0.CO