Modulation of Mitochondrial Dynamics in Neurodegenerative Diseases: An Insight Into Prion Diseases

被引:38
作者
Zhu, Ting [1 ]
Chen, Ji-Long [1 ]
Wang, Qingsen [1 ]
Shao, Wenhan [1 ]
Qi, Baomin [1 ]
机构
[1] Fujian Agr & Forestry Univ, Coll Anim Sci, Key Lab Fujian Taiwan Anim Pathogen Biol, Fuzhou, Fujian, Peoples R China
关键词
prion diseases; neurodegenerative diseases; mitochondrial dysfunction; mitochondrial dynamics; mitophagy; therapeutic target; DEFECTIVE AXONAL-TRANSPORT; ALZHEIMERS-DISEASE; PROTEIN DRP1; SYNAPTIC DEGENERATION; HUNTINGTONS-DISEASE; MUTANT HUNTINGTIN; OXIDATIVE STRESS; AMYLOID-BETA; PINK1/PARKIN-MEDIATED MITOPHAGY; ABNORMAL INTERACTION;
D O I
10.3389/fnagi.2018.00336
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Mitochondrial dysfunction is a common and prominent feature of prion diseases and other neurodegenerative disorders. Mitochondria are dynamic organelles that constantly fuse with one another and subsequently break apart. Defective or superfluous mitochondria are usually eliminated by a form of autophagy, referred to as mitophagy, to maintain mitochondrial homeostasis. Mitochondrial dynamics are tightly regulated by processes including fusion and fission. Dysfunction of mitochondrial dynamics can lead to the accumulation of abnormal mitochondria and contribute to cellular damage. Neurons are among the cell types that consume the most energy, have a highly complex morphology, and are particularly dependent on mitochondrial functions and dynamics. In this review article, we summarize the molecular mechanisms underlying the mitochondrial dynamics and the regulation of mitophagy and discuss the dysfunction of these processes in the progression of prion diseases and other neurodegenerative disorders. We have also provided an overview of mitochondrial dynamics as a therapeutic target for neurodegenerative diseases.
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页数:10
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