Progressive disease in chronic lymphocytic leukemia is correlated with the DNA methylation index

被引：9

作者：

Yu, Margaret K.

Bergonia, Hector

Szabo, Aniko

Phillips, John D.

机构：

[1] Univ Utah, Huntsman Canc Inst, Dept Internal Med, Div Hematol, Salt Lake City, UT 84112 USA

[2] Univ Utah, Sch Med, Div Hematol, Dept Internal Med, Salt Lake City, UT 84112 USA

[3] Univ Utah, Dept Oncol Sci, Huntsman Canc Inst, Salt Lake City, UT 84112 USA

来源：

LEUKEMIA RESEARCH | 2007年 / 31卷 / 06期

关键词：

DNA methylation; chronic lymphocytic leukemia; progressive diseased hypermethylation; hypomethylation;

D O I：

10.1016/j.leukres.2006.07.007

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The DNA methylation index (MI) is calculated as a percentage of methylated cytosines to cytosines. We established the DNA MI in 100 normal individuals ranging in age between I month and 94 years and found that the age-specific DNA MI can be calculated (4.00-0.0034 x age). We determined the DNA MI in 23 patients with CLL ranging from 47 to 90 years and compared the results with age-matched controls. Using Cox proportional hazard models for MI, adjusting for age and white blood cell count, only the DNA MI correlated with early clinical indications for systemic therapy (p = 0.0038, FIR = 7.00, 95% CI: 1.90-26.20). (c) 2006 Elsevier Ltd. All rights reserved.

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收藏

页码：773 / 777

页数：5

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