Is P-glycoprotein Involved in Amyloid-β Elimination Across the Blood-Brain Barrier in Alzheimer's Disease?

被引：15
|
作者：
Ohtsuki, S. [1 ]
Ito, S. [1 ]
Terasaki, T. [1 ]
机构：
[1] Tohoku Univ, Grad Sch Pharmaceut Sci, Div Membrane Transport & Drug Targeting, Sendai, Miyagi 980, Japan
来源：
CLINICAL PHARMACOLOGY & THERAPEUTICS | 2010年 / 88卷 / 04期
关键词：
IN-VITRO MODEL; DEPOSITION; CLEARANCE; PEPTIDES;
D O I：
10.1038/clpt.2010.160
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
引用
收藏
页码：443 / 445
页数：4
相关论文
共 50 条
  • [1] Transport of amyloid-β across the blood-brain barrier by P-glycoprotein: A novel therapeutic target in Alzheimer's disease
    Holt, Hope
    Moore, Elizabeth
    Riese, Madeline
    Faucett, Michelle
    Gonzalez, Francisco
    Moss, Melissa
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 256
  • [2] Restoring Blood-Brain Barrier P-Glycoprotein Reduces Brain Amyloid-β in a Mouse Model of Alzheimer's Disease
    Hartz, Anika M. S.
    Miller, David S.
    Bauer, Bjoern
    MOLECULAR PHARMACOLOGY, 2010, 77 (05) : 715 - 723
  • [3] P-glycoprotein deficiency at the blood-brain barrier increases amyloid-β deposition in an Alzheimer disease mouse model
    Cirrito, JR
    Deane, R
    Fagan, AM
    Spinner, ML
    Parsadanian, M
    Finn, MB
    Jiang, H
    Prior, JL
    Sagare, A
    Bales, KR
    Paul, SM
    Zlokovic, BV
    Piwnica-Worms, D
    Holtzman, DM
    JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11): : 3285 - 3290
  • [4] Blood-brain barrier P-glycoprotein function in Alzheimer's disease
    van Assema, Danielle M. E.
    Lubberink, Mark
    Bauer, Martin
    van der Flier, Wiesje M.
    Schuit, Robert C.
    Windhorst, Albert D.
    Comans, Emile F. I.
    Hoetjes, Nikie J.
    Tolboom, Nelleke
    Langer, Oliver
    Mueller, Markus
    Scheltens, Philip
    Lammertsma, Adriaan A.
    van Berckel, Bart N. M.
    BRAIN, 2012, 135 : 181 - 189
  • [5] Blood-brain barrier P-glycoprotein: a new target for Alzheimer's disease?
    Hartz, A. M.
    JOURNAL OF NEUROCHEMISTRY, 2013, 125 : 39 - 39
  • [6] Amyloid-β Peptides, Alzheimer's Disease and the Blood-brain Barrier
    Gosselet, Fabien
    Saint-Pol, Julien
    Candela, Pietra
    Fenart, Laurence
    CURRENT ALZHEIMER RESEARCH, 2013, 10 (10) : 1015 - 1033
  • [7] Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimer's Disease
    Deane, R.
    Bell, R. D.
    Sagare, A.
    Zlokovic, B. V.
    CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS, 2009, 8 (01) : 16 - 30
  • [8] Activity of P-Glycoprotein, a β-Amyloid Transporter at the Blood-Brain Barrier, Is Compromised in Patients with Mild Alzheimer Disease
    Deo, Anand K.
    Borson, Soo
    Link, Jeanne M.
    Domino, Karen
    Eary, Janet F.
    Ke, Ban
    Richards, Todd L.
    Mankoff, David A.
    Minoshima, Satoshi
    O'Sullivan, Finbarr
    Eyal, Sara
    Hsiao, Peng
    Maravilla, Ken
    Unadkat, Jashvant D.
    JOURNAL OF NUCLEAR MEDICINE, 2014, 55 (07) : 1106 - 1111
  • [9] P-glycoprotein: a role in the export of amyloid-β in Alzheimer's disease?
    Chai, Amanda B.
    Leung, Gavin K. F.
    Callaghan, Richard
    Gelissen, Ingrid C.
    FEBS JOURNAL, 2020, 287 (04) : 612 - 625
  • [10] Blood-brain barrier permeability correlates with medial temporal lobe atrophy but not with amyloid-β protein transport across the blood-brain barrier in Alzheimer's disease
    Matsumoto, Yasuko
    Yanase, Daisuke
    Noguchi-Shinohara, Moeko
    Ono, Kenjiro
    Yoshita, Mitsuhiro
    Yamada, Masahito
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2007, 23 (04) : 241 - 245
12345