Efficient direct 2,2,2-trifluoroethylation of indoles via C-H functionalization

被引：67

作者：

Tolnai, Gergely L. ^{[1
]}

Szekely, Anna ^{[1
]}

Mako, Zita ^{[1
]}

Gati, Tamas ^{[2
]}

Daru, Janos ^{[3
]}

Bihari, Tamas ^{[3
]}

Stirling, Andras ^{[3
]}

Novak, Zoltan ^{[1
]}

机构：

[1] Eotvos Lorand Univ, Fac Sci, Inst Chem, MTA ELTE Lendulet Catalysis & Organ Synth Res Grp, H-1117 Budapest, Hungary

[2] Servier Res Inst Med Chem, H-1031 Budapest, Hungary

[3] Hungarian Acad Sci, Res Ctr Nat Sci, Dept Theoret Chem, H-1117 Budapest, Hungary

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 21期

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLTHIOLATION; CROSS-COUPLING REACTIONS; DIARYLIODONIUM SALTS; DIRECT ALKYNYLATION; ALKYNES; ARYL; TRIFLUOROETHYLATION; ALDEHYDES; REAGENTS; ALKENES;

D O I：

10.1039/c5cc00519a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel highly C3 selective metal free trifluoroethylation of indoles using 2,2,2-trifuoroethyl(mesityl)-iodonium triflate was developed. The methodology enables the introduction of a trifluoroethyl group in a fast and efficient reaction under mild conditions with high functional group tolerance. Beyond the synthetic developments, quantum chemical calculations provide a deeper understanding of the transformation.

引用

页码：4488 / 4491

页数：4

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