Magnesium glassy alloy laminated nanofibrous polymer as biodegradable scaffolds

Magnesium-based thin film metallic glass (MgMG) has recently pulled in huge attraction for biomedical implants because of their promising biocompatibility, biodegradability, and better, mechanical properties. In this study, biodegradable polycaprolactone (PCL) and nano-hydroxyapatite (nHA) are electrospun at various PCL/nHA concentration and used as scaffolds. Mg-Zn-Ca thin film metallic glasses were sputtered over the scaffold by DC magnetron sputtering process to obtain surface modified scaffolds of (PCL/MgMG) and (PCL/nHA/MgMG). Magnesium metallic glass coatings neither alter the structure of the scaffold or the rate of magnesium release nor weight loss, compared with the uncoated scaffold. The changes within the crystallinity, wettability, and oxygen content of sputtered coating not solely improve the mechanical adhesion strength; however additionally increase the biological response with controlled biodegradation. Moreover, the modified specimen prompt higher hemocompatibility, due to the change in wettability from 127 to 48 degrees and due to C-O to C=O functional group ratio. These promising outcomes uncover the clinical potential of the surface modified coating of magnesium metallic glass on PCL and PCL/nHA scaffolds as degradable implants.