Outcome of Percutaneous Bone Marrow Injection in Femoral Delayed Union and Nonunion

Background: The benefits of autologous bone grafts on bone healing have been recognized for over 100 years. Osteoprogenitor cells aspirated from bone marrow have shown to provide key stimulus for osteogenesis. Regardless of their osteogenic characteristics, the clinical utilization of marrow as an osteogenic source has remained limited. Aim: To ascertain radiological union with percutaneous autologous bone marrow injection in delayed union and nonunion of femur. Methodology: This is a descriptive case series study, 35 patients were included in this study and carried out in Orthopaedic Department at Pak Red Crescent Medical College Kasur, 6 months of period from May 2019 to October 2019. Age of patients was 18-60 years of both sexes. Radiographs of affected side were performed to document cases of delayed and nonunion. 50ml of bone marrow aspirated in small fractions from iliac crest was injected at affected site. Results were evaluated at the end of 12 weeks with the help of radiograph. Results: In this study 33 (94.3%) were males and 2 (5.7%) were females. Mean age was 33.80 +/- 10.16 years. Radiological union was achieved in 26 (74.3%) patients. Conclusion: Percutaneous bone marrow injection is safe procedure without operative morbidity with bone healing in average time of 12 weeks.