Persisting corneal erosion under cetuximab (Erbitux) treatment (Epidermal growth factor receptor antibody)

被引：58

作者：

Foerster, Claudia G. ^{[1
]}

Cursiefen, Claus ^{[1
]}

Kruse, Friedrich E. ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Ophthalmol, D-91054 Erlangen, Germany

来源：

CORNEA | 2008年 / 27卷 / 05期

关键词：

epidermal growth factor; epidermal growth factor receptor; epidermal growth factor receptor antibody; impairment of corneal wound healing;

D O I：

10.1097/ICO.0b013e318166f483

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Purpose: To report persisting corneal erosion and trichomegaly as ocular side effects of cetuximab (Erbitux) treatment, a monoclonal antibody against the epidermal growth factor (EGF) receptor. Methods: A 62-year-old patient was treated with combined chemotherapy including cetuximab for colorectal carcinoma and showed accelerated growth of eyelashes with persistent bilateral corneal erosions resistant to conservative treatment. Topical EGF was successfully applied as an experimental treatment to antagonize the inhibitory effect of the EGF receptor antibody. Results: Topical application of EGF led to rapid improvement, with complete healing of the epithelial defect after 7 (left eye) and 19 days (right eye) while application of cetuximab was continued. Conclusions: Cetuximab (Erbitux) can cause impairment of corneal wound healing as an ocular side effect. Patients concerned may benefit from application of EGF eyedrops.

引用

页码：612 / 614

页数：3

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