Advances in metal-carbene complexes as potent anti-cancer agents

被引：266
作者：
Gautier, Arnaud [1 ,2 ]
Cisnetti, Federico [2 ]
机构：
[1] CNRS, UMR 6504, F-63177 Aubiere, France
[2] Univ Blaise Pascal, Clermont Univ, Lab SEESIB, F-63000 Clermont Ferrand, France
来源：
METALLOMICS | 2012年 / 4卷 / 01期
关键词：
N-HETEROCYCLIC CARBENE; COORDINATED GOLD COMPOUND; IN-VITRO; ANTITUMOR-ACTIVITY; CLIP-PHEN; PHASE-I; CYTOTOXICITY; PALLADIUM; RUTHENIUM; VIVO;
D O I：
10.1039/c1mt00123j
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
This critical review is an updated survey of metal-carbenes as potential anticancer chemotherapeutics. We report on the recent advances in the discovery of N-heterocyclic carbenes, acyclic diamino carbenes and abnormal NHCs associated with metals from groups 10 and 11 that displayed antiproliferative activity and emphasize, when possible, their molecular target(s) and their mechanism of action.
引用
收藏
页码：23 / 32
页数：10
相关论文
共 96 条
  • [11] Mitochondrial permeability transition induced by dinuclear gold(I)-carbene complexes: potential new antimitochondrial antitumour agents
    Barnard, PJ
    Baker, MV
    Berners-Price, SJ
    Day, DA
    [J]. JOURNAL OF INORGANIC BIOCHEMISTRY, 2004, 98 (10) : 1642 - 1647
  • [12] Dinuclear gold(I) complexes of bridging bidentate carbene ligands: synthesis, structure and spectroscopic characterisation
    Barnard, PJ
    Baker, MV
    Berners-Price, SJ
    Skelton, BW
    White, AH
    [J]. DALTON TRANSACTIONS, 2004, (07) : 1038 - 1047
  • [13] Gold compounds as therapeutic agents for human diseases
    Berners-Price, Susan J.
    Filipovska, Aleksandra
    [J]. METALLOMICS, 2011, 3 (09) : 863 - 873
  • [14] Activating Platinum Anticancer Complexes with Visible Light
    Berners-Price, Susan J.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2011, 50 (04) : 804 - 805
  • [15] Synthetic and structural studies of NHC-Pt(dvtms) complexes and their application as alkene hydrosilylation catalysts (NHC = N-heterocyclic carbene, dvtms = divinyltetramethylsiloxane)
    Berthon-Gelloz, G
    Buisine, O
    Brière, JF
    Michaud, G
    Stérin, S
    Mignani, G
    Tinant, B
    Declercq, JP
    Chapon, D
    Markó, IE
    [J]. JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2005, 690 (24-25) : 6156 - 6168
  • [16] Bratsos I., 2011, Bioinorganic Medicinal Chemistry, P151, DOI DOI 10.1002/9783527633104.CH5
  • [17] PALLADIUM AND PLATINUM COMPLEXES RESULTING FROM ADDITION OF HYDRAZINE TO COORDINATED ISOCYANIDE
    BURKE, A
    BALCH, AL
    ENEMARK, JH
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1970, 92 (08) : 2555 - +
  • [18] Cetinkaya B, 1996, ARZNEIMITTEL-FORSCH, V46, P821
  • [19] Direct functionalisation of group 10 N-heterocyclic carbene complexes for diversity enhancement
    Chardon, Edith
    Puleo, Gian Luigi
    Dahm, Georges
    Guichard, Gilles
    Bellemin-Laponnaz, Stephane
    [J]. CHEMICAL COMMUNICATIONS, 2011, 47 (20) : 5864 - 5866
  • [20] Therapeutic applications of gold complexes: lipophilic gold(III) cations and gold(I) complexes for anti-cancer treatment
    Che, Chi-Ming
    Sun, Raymond Wai-Yin
    [J]. CHEMICAL COMMUNICATIONS, 2011, 47 (34) : 9554 - 9560
12345678910