The updated biology of hypoxia-inducible factor

被引：452
作者：
Greer, Samantha N. [1 ]
Metcalf, Julie L. [1 ]
Wang, Yi [1 ]
Ohh, Michael [1 ]
机构：
[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada
来源：
EMBO JOURNAL | 2012年 / 31卷 / 11期
基金：
加拿大健康研究院;
关键词：
development; HIF; hypoxia; immunity; stem cell biology; NF-KAPPA-B; EMBRYONIC STEM-CELLS; PYRUVATE-KINASE; GENE-EXPRESSION; FACTOR; 1-ALPHA; TUMOR-GROWTH; HIF-ALPHA; TRANSCRIPTIONAL REGULATION; PROLYL HYDROXYLATION; ENERGY-METABOLISM;
D O I：
10.1038/emboj.2012.125
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of multicellular organisms. Proper cellular response to changes in oxygen tension during normal development or pathological processes, such as cardiovascular disease and cancer, is ultimately regulated by the transcription factor, hypoxia-inducible factor (HIF). Over the past decade, unprecedented molecular insight has been gained into the mammalian oxygen-sensing pathway involving the canonical oxygen-dependent prolyl-hydroxylase domain-containing enzyme (PHD)-von Hippel-Lindau tumour suppressor protein (pVHL) axis and its connection to cellular metabolism. Here we review recent notable advances in the field of hypoxia that have shaped a more complex model of HIF regulation and revealed unique roles of HIF in a diverse range of biological processes, including immunity, development and stem cell biology. The EMBO Journal (2012) 31, 2448-2460. doi: 10.1038/emboj.2012.125; Published online 4 May 2012
引用
收藏
页码：2448 / 2460
页数：13
相关论文
共 131 条
  • [61] Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates -: Possible links between cell metabolism and stabilization of HIF
    Koivunen, Peppi
    Hirsila, Maija
    Remes, Anne M.
    Hassinen, Ilmo E.
    Kivirikko, Kari I.
    Myllyharju, Johanna
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (07) : 4524 - 4532
  • [62] Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice
    Kojima, H
    Gu, H
    Nomura, S
    Caldwell, CC
    Kobata, T
    Carmeliet, P
    Semenza, GL
    Sitkovsky, MV
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) : 2170 - 2174
  • [63] Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α-Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow
    Kojima, Hidefumi
    Kobayashi, Ayano
    Sakurai, Daisuke
    Kanno, Yumiko
    Hase, Hidenori
    Takahashi, Riichi
    Totsuka, Yoshikazu
    Semenza, Gregg L.
    Sitkovsky, Michail V.
    Kobata, Tetsuji
    [J]. JOURNAL OF IMMUNOLOGY, 2010, 184 (01) : 154 - 163
  • [64] Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction Of β2 integrin gene expression
    Kong, TQ
    Eltzschig, HK
    Karhausen, J
    Colgan, SP
    Shelley, CS
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (28) : 10440 - 10445
  • [65] Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
    Lando, D
    Peet, DJ
    Whelan, DA
    Gorman, JJ
    Whitelaw, ML
    [J]. SCIENCE, 2002, 295 (5556) : 858 - 861
  • [66] Hypoxia-induced methylation of a pontin chromatin remodeling factor
    Lee, Jason S.
    Kim, Yunho
    Bhin, Jinhyuk
    Shin, Hi-Jai R.
    Nam, Hye Jin
    Lee, Seung Hoon
    Yoon, Jong-Bok
    Binda, Olivier
    Gozani, Or
    Hwang, Daehee
    Baek, Sung Hee
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) : 13510 - 13515
  • [67] Activin Signaling: Effects on Body Composition and Mitochondrial Energy Metabolism
    Li, Liunan
    Shen, Joseph J.
    Bournat, Juan C.
    Huang, Lihua
    Chattopadhyay, Abanti
    Li, Zhihong
    Shaw, Chad
    Graham, Brett H.
    Brown, Chester W.
    [J]. ENDOCRINOLOGY, 2009, 150 (08) : 3521 - 3529
  • [68] Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
    Lim, Ji-Hong
    Lee, Yoon-Mi
    Chun, Yang-Sook
    Chen, Junjie
    Kim, Ja-Eun
    Park, Jong-Wan
    [J]. MOLECULAR CELL, 2010, 38 (06) : 864 - 878
  • [69] Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
    Lombard, David B.
    Alt, Frederick W.
    Cheng, Hwei-Ling
    Bunkenborg, Jakob
    Streeper, Ryan S.
    Mostoslavsky, Raul
    Kim, Jennifer
    Yancopoulos, George
    Valenzuela, David
    Murphy, Andrew
    Yang, Yinhua
    Chen, Yaohui
    Hirschey, Matthew D.
    Bronson, Roderick T.
    Haigis, Marcia
    Guarente, Leonard P.
    Farese, Robert V., Jr.
    Weissman, Sherman
    Verdin, Eric
    Schwer, Bjoern
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (24) : 8807 - 8814
  • [70] Selective induction of mucin-3 by hypoxia in intestinal epithelia
    Louis, Nancy A.
    Hamilton, Kathryn E.
    Canny, Geraldine
    Shekels, Laurie L.
    Ho, Samuel B.
    Colgan, Sean P.
    [J]. JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 99 (06) : 1616 - 1627
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