The updated biology of hypoxia-inducible factor

被引：458

作者：

Greer, Samantha N. ^{[1
]}

Metcalf, Julie L. ^{[1
]}

Wang, Yi ^{[1
]}

Ohh, Michael ^{[1
]}

机构：

[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada

来源：

EMBO JOURNAL | 2012年 / 31卷 / 11期

基金：

加拿大健康研究院;

关键词：

development; HIF; hypoxia; immunity; stem cell biology; NF-KAPPA-B; EMBRYONIC STEM-CELLS; PYRUVATE-KINASE; GENE-EXPRESSION; FACTOR; 1-ALPHA; TUMOR-GROWTH; HIF-ALPHA; TRANSCRIPTIONAL REGULATION; PROLYL HYDROXYLATION; ENERGY-METABOLISM;

D O I：

10.1038/emboj.2012.125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of multicellular organisms. Proper cellular response to changes in oxygen tension during normal development or pathological processes, such as cardiovascular disease and cancer, is ultimately regulated by the transcription factor, hypoxia-inducible factor (HIF). Over the past decade, unprecedented molecular insight has been gained into the mammalian oxygen-sensing pathway involving the canonical oxygen-dependent prolyl-hydroxylase domain-containing enzyme (PHD)-von Hippel-Lindau tumour suppressor protein (pVHL) axis and its connection to cellular metabolism. Here we review recent notable advances in the field of hypoxia that have shaped a more complex model of HIF regulation and revealed unique roles of HIF in a diverse range of biological processes, including immunity, development and stem cell biology. The EMBO Journal (2012) 31, 2448-2460. doi: 10.1038/emboj.2012.125; Published online 4 May 2012

引用

页码：2448 / 2460

页数：13

共 131 条

[61] Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates -: Possible links between cell metabolism and stabilization of HIF [J].

Koivunen, Peppi ;

Hirsila, Maija ;

Remes, Anne M. ;

Hassinen, Ilmo E. ;

Kivirikko, Kari I. ;

Myllyharju, Johanna .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (07) :4524-4532

[62] Abnormal B lymphocyte development and autoimmunity in hypoxia-inducible factor 1α-deficient chimeric mice [J].

Kojima, H ;

Gu, H ;

Nomura, S ;

Caldwell, CC ;

Kobata, T ;

Carmeliet, P ;

Semenza, GL ;

Sitkovsky, MV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (04) :2170-2174

[63] Differentiation Stage-Specific Requirement in Hypoxia-Inducible Factor-1α-Regulated Glycolytic Pathway during Murine B Cell Development in Bone Marrow [J].

Kojima, Hidefumi ;

Kobayashi, Ayano ;

Sakurai, Daisuke ;

Kanno, Yumiko ;

Hase, Hidenori ;

Takahashi, Riichi ;

Totsuka, Yoshikazu ;

Semenza, Gregg L. ;

Sitkovsky, Michail V. ;

Kobata, Tetsuji .

JOURNAL OF IMMUNOLOGY, 2010, 184 (01) :154-163

[64] Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction Of β2 integrin gene expression [J].

Kong, TQ ;

Eltzschig, HK ;

Karhausen, J ;

Colgan, SP ;

Shelley, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (28) :10440-10445

[65] Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch [J].

Lando, D ;

Peet, DJ ;

Whelan, DA ;

Gorman, JJ ;

Whitelaw, ML .

SCIENCE, 2002, 295 (5556) :858-861

[66] Hypoxia-induced methylation of a pontin chromatin remodeling factor [J].

Lee, Jason S. ;

Kim, Yunho ;

Bhin, Jinhyuk ;

Shin, Hi-Jai R. ;

Nam, Hye Jin ;

Lee, Seung Hoon ;

Yoon, Jong-Bok ;

Binda, Olivier ;

Gozani, Or ;

Hwang, Daehee ;

Baek, Sung Hee .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (33) :13510-13515

[67] Activin Signaling: Effects on Body Composition and Mitochondrial Energy Metabolism [J].

Li, Liunan ;

Shen, Joseph J. ;

Bournat, Juan C. ;

Huang, Lihua ;

Chattopadhyay, Abanti ;

Li, Zhihong ;

Shaw, Chad ;

Graham, Brett H. ;

Brown, Chester W. .

ENDOCRINOLOGY, 2009, 150 (08) :3521-3529

[68] Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α [J].

Lim, Ji-Hong ;

Lee, Yoon-Mi ;

Chun, Yang-Sook ;

Chen, Junjie ;

Kim, Ja-Eun ;

Park, Jong-Wan .

MOLECULAR CELL, 2010, 38 (06) :864-878

[69] Mammalian sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation [J].

Lombard, David B. ;

Alt, Frederick W. ;

Cheng, Hwei-Ling ;

Bunkenborg, Jakob ;

Streeper, Ryan S. ;

Mostoslavsky, Raul ;

Kim, Jennifer ;

Yancopoulos, George ;

Valenzuela, David ;

Murphy, Andrew ;

Yang, Yinhua ;

Chen, Yaohui ;

Hirschey, Matthew D. ;

Bronson, Roderick T. ;

Haigis, Marcia ;

Guarente, Leonard P. ;

Farese, Robert V., Jr. ;

Weissman, Sherman ;

Verdin, Eric ;

Schwer, Bjoern .

MOLECULAR AND CELLULAR BIOLOGY, 2007, 27 (24) :8807-8814

[70] Selective induction of mucin-3 by hypoxia in intestinal epithelia [J].

Louis, Nancy A. ;

Hamilton, Kathryn E. ;

Canny, Geraldine ;

Shekels, Laurie L. ;

Ho, Samuel B. ;

Colgan, Sean P. .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2006, 99 (06) :1616-1627

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