The updated biology of hypoxia-inducible factor

被引：452
作者：
Greer, Samantha N. [1 ]
Metcalf, Julie L. [1 ]
Wang, Yi [1 ]
Ohh, Michael [1 ]
机构：
[1] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON M5S 1A8, Canada
来源：
EMBO JOURNAL | 2012年 / 31卷 / 11期
基金：
加拿大健康研究院;
关键词：
development; HIF; hypoxia; immunity; stem cell biology; NF-KAPPA-B; EMBRYONIC STEM-CELLS; PYRUVATE-KINASE; GENE-EXPRESSION; FACTOR; 1-ALPHA; TUMOR-GROWTH; HIF-ALPHA; TRANSCRIPTIONAL REGULATION; PROLYL HYDROXYLATION; ENERGY-METABOLISM;
D O I：
10.1038/emboj.2012.125
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Oxygen is essential for eukaryotic life and is inextricably linked to the evolution of multicellular organisms. Proper cellular response to changes in oxygen tension during normal development or pathological processes, such as cardiovascular disease and cancer, is ultimately regulated by the transcription factor, hypoxia-inducible factor (HIF). Over the past decade, unprecedented molecular insight has been gained into the mammalian oxygen-sensing pathway involving the canonical oxygen-dependent prolyl-hydroxylase domain-containing enzyme (PHD)-von Hippel-Lindau tumour suppressor protein (pVHL) axis and its connection to cellular metabolism. Here we review recent notable advances in the field of hypoxia that have shaped a more complex model of HIF regulation and revealed unique roles of HIF in a diverse range of biological processes, including immunity, development and stem cell biology. The EMBO Journal (2012) 31, 2448-2460. doi: 10.1038/emboj.2012.125; Published online 4 May 2012
引用
收藏
页码：2448 / 2460
页数：13
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