The physics, biophysics and technology of photodynamic therapy

被引：765
作者：
Wilson, Brian C. [1 ,2 ]
Patterson, Michael S. [3 ,4 ]
机构：
[1] Univ Toronto, Ontario Canc Inst, Div Biophys & Bioimaging, Toronto, ON M5G 2M9, Canada
[2] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2M9, Canada
[3] McMaster Univ, Juravinski Canc Ctr, Dept Med Phys, Hamilton, ON L8V 5CS, Canada
[4] McMaster Univ, Dept Med Phys & Appl Radiat Sci, Hamilton, ON L8V 5CS, Canada
来源：
PHYSICS IN MEDICINE AND BIOLOGY | 2008年 / 53卷 / 09期
关键词：
D O I：
10.1088/0031-9155/53/9/R01
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Photodynamic therapy (PDT) uses light-activated drugs to treat diseases ranging from cancer to age-related macular degeneration and antibiotic-resistant infections. This paper reviews the current status of PDT with an emphasis on the contributions of physics, biophysics and technology, and the challenges remaining in the optimization and adoption of this treatment modality. A theme of the review is the complexity of PDT dosimetry due to the dynamic nature of the three essential components-light, photosensitizer and oxygen. Considerable progress has been made in understanding the problem and in developing instruments to measure all three, so that optimization of individual PDT treatments is becoming a feasible target. The final section of the review introduces some new frontiers of research including low dose rate (metronomic) PDT, two-photon PDT, activatable PDT molecular beacons and nanoparticle-based PDT.
引用
收藏
页码：R61 / R109
页数：49
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