Dan-Shen-Yin protects the heart against inflammation and oxidative stress induced by acute ischemic myocardial injury in rats

被引：22

作者：

Yan, Kui-Po ^{[1
]}

Guo, Yong ^{[2
,3
]}

Xing, Zhihua ^{[1
]}

Huang, Xi ^{[1
]}

Dai, Shengping

Duan, Min ^{[4
]}

Sun, Xinhua

Huang, Wei ^{[1
]}

Peng, Weijun ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Inst Integrated Tradit Med & Western Med, Changsha 410008, Hunan, Peoples R China

[2] Cent S Univ, Xiangya Hosp, Dept Neurosurg, Changsha 410008, Hunan, Peoples R China

[3] PLA 152 Cent Hosp, Dept Cardiol, Pingdingshan 467000, Peoples R China

[4] Henan Coll TCM, Affiliated Hosp 1, Dept Cardiol, Zhengzhou 450008, Peoples R China

来源：

EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2012年 / 3卷 / 02期

关键词：

traditional Chinese formula; Dan-Shen-Yin; coronary heart disease; inflammation; oxidative stress; C-REACTIVE PROTEIN; XIN-ER-HAO; REPERFUSION; APOPTOSIS; DISEASE; PLASMA; CRP;

D O I：

10.3892/etm.2011.404

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Dan-Shen-Yin (DSY) is a well-known traditional Chinese formula which is widely used in clinical practice for the treatment of coronary heart disease (CH D) and has produced a favorable effect in China. The present study was designed to examine whether or not acute oral DSY can protect the heart against myocardial infarction in acute myocardial ischemic rats. If so, we would then investigate the anti-inflammatory and anti-oxidant mechanisms involved. The left anterior descending coronary artery was occluded to induce myocardial ischemia in the hearts of Sprague-Dawley rats. At the end of the 3-h ischemic period (or 24 h for infarction size), we measured the myocardial infarction size, inflammatory factors and the activities of anti-oxidative enzymes. DSY reduced the infarction size and the serum levels of C-reactive protein, interleukin-6, tumour necrosis factor-a and malondialdehyde and increased the activities of superoxide dismutase and the serum levels of glutathione. The results show that DSY exerts significant cardioprotective effects against acute ischemic myocardial injury in rats, possibly through its anti-inflammatory and anti-oxidant properties, and may thus be used as a potential therapeutic reagent for the treatment of CHD.

引用

页码：314 / 318

页数：5

共 41 条

[1]

Abbas A.K., 1991, CELL MOL IMMUNOL, P226

[2] CRP after 2004 [J].

Agrawal, A .

MOLECULAR IMMUNOLOGY, 2005, 42 (08) :927-930

[3] ACC/AHA 2007 Guidelines for the Management of Patients With unstable Angina/Non-ST-Elevation Myocardial Infarction A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine [J].

Anderson, Jeffrey L. ;

Adams, Cynthia D. ;

Antman, Elliott M. ;

Bridges, Charles R. ;

Califf, Robert M. ;

Casey, Donald E., Jr. ;

Chavey, William E. ;

Fesmire, Francis M. ;

Hochman, Judith S. ;

Levin, Thomas N. ;

Lincoff, A. Michael ;

Peterson, Eric D. ;

Theroux, Pierre ;

Wenger, Nanette Kass ;

Wright, R. Scott ;

Smith, Sidney C. ;

Jacobs, Alice K. ;

Halperin, Jonathan L. ;

Hunt, Sharon A. ;

Krumholz, Harlan M. ;

Kushner, Frederick G. ;

Lytle, Bruce W. ;

Nishimura, Rick ;

Ornato, Joseph P. ;

Page, Richard L. ;

Riegel, Barbara .

CIRCULATION, 2007, 116 (07) :E148-E304

[4]

[Anonymous], J NEW CHINESE MED

[5]

[Anonymous], CHIN MED MOD DIST ED

[6]

[Anonymous], CHIN J TRADIT MED SC

[7]

[Anonymous], 2010, CHIN J INTEGR MED CA

[8] C-Reactive Protein as a Risk Factor for Coronary Heart Disease: A Systematic Review and Meta-analyses for the US Preventive Services Task Force [J].

Buckley, David I. ;

Fu, Rongwei ;

Freeman, Michele ;

Rogers, Kevin ;

Helfand, Mark .

ANNALS OF INTERNAL MEDICINE, 2009, 151 (07) :483-W161

[9] Herbal and Traditional Chinese Medicine for the Treatment of Cardiovascular Complications in Diabetes Mellitus [J].

Ceylan-Isik, Asli F. ;

Fliethman, Rochelle M. ;

Wold, Loren E. ;

Ren, Jun .

CURRENT DIABETES REVIEWS, 2008, 4 (04) :320-328

[10] Total Phenolics Level, Antioxidant Activities and Cytotoxicity of Young Sprouts of Some Traditional Korean Salad Plants [J].

Chon, Sang-Uk ;

Heo, Buk-Gu ;

Park, Yong-Seo ;

Kim, Dong-Kwan ;

Gorinstein, Shela .

PLANT FOODS FOR HUMAN NUTRITION, 2009, 64 (01) :25-31

← 1 2 3 4 5 →