Mediastinal Malignant Melanoma Markedly Shrinking in Response to Nivolumab

被引：0

作者：

Sakaguchi, Hiroyuki ^{[1
]}

Tanimoto, Azusa ^{[1
]}

Sato, Shigeki ^{[1
]}

Yanagimura, Naohiro ^{[1
]}

Suzuki, Chiaki ^{[1
]}

Takumi, Yohei ^{[1
]}

Nishiyama, Akihiro ^{[1
]}

Yamashita, Kaname ^{[1
]}

Takeuchi, Shinji ^{[1
]}

Ohtsubo, Koshiro ^{[1
]}

Yano, Seiji ^{[1
,2
]}

机构：

[1] Kanazawa Univ, Canc Res Inst, Div Med Oncol, Kanazawa, Ishikawa, Japan

[2] Kanazawa Univ, WPI Nano Life Sci Inst WPI Nano LSI, Kanazawa, Ishikawa, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 01期

关键词：

mediastinal tumor; malignant melanoma; nivolumab; immunotherapy; IPILIMUMAB;

D O I：

10.2169/internalmedicine.7452-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Primary malignant melanoma (MM) of the mediastinum is rare, and there is a lack of consensus regarding the preferred treatment because non-cutaneous MM demonstrates an inferior response to systemic therapy. Herein, we describe the case of a 73-year-old man with MM of the anterior mediastinum with multiple liver metastases. Even though the size of lesions increased rapidly following diagnosis, nivolumab monotherapy caused remarkable tumor shrinkage. This is the first report of mediastinal MM showing a significant response to nivolumab. We, therefore, suggest that immunotherapy may be one of the treatment options for primary mediastinal MM.

引用

页码：75 / 79

页数：5

共 11 条

[1] Protein induced by vitamin K absence or antagonist-II production is a strong predictive marker for extrahepatic metastases in early hepatocellular carcinoma: a prospective evaluation
Bae, Hyun-Mi
Lee, Jeong-Hoon
Yoon, Jung-Hwan
Kim, Yoon Jun
Heo, Dae Seog
Lee, Hyo-Suk
[J]. BMC CANCER, 2011, 11
[2] Efficacy and Safety of Nivolumab Alone or in Combination With Ipilimumab in Patients With Mucosal Melanoma: A Pooled Analysis
D'Angelo, Sandra P.
Larkin, James
Sosman, Jeffrey A.
Lebbe, Celeste
Brady, Benjamin
Neyns, Bart
Schmidt, Henrik
Hassel, Jessica C.
Hodi, F. Stephen
Lorigan, Paul
Savage, Kerry J.
Miller, Wilson H., Jr.
Mohr, Peter
Marquez-Rodas, Ivan
Charles, Julie
Kaatz, Martin
Sznol, Mario
Weber, Jeffrey S.
Shoushtari, Alexander N.
Ruisi, Mary
Jiang, Joel
Wolchok, Jedd D.
[J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (02) : 226 - +
[3] Six cases of metastatic malignant melanoma with apparently occult primary lesions
Honda, S
Yamamoto, O
Suenaga, Y
Asahi, M
Nakayama, K
[J]. JOURNAL OF DERMATOLOGY, 2001, 28 (05) : 265 - 271
[4] A diagnostic approach to the mediastinal masses
Juanpere, Sergi
Canete, Noemi
Ortuno, Pedro
Martinez, Sandra
Sanchez, Gloria
Bernado, Lluis
[J]. INSIGHTS INTO IMAGING, 2013, 4 (01): : 29 - 52
[5] Primary malignant melanoma: A rare cause of mediastinal mass
Karuppiah S.V.
Buchan K.G.
[J]. The Japanese Journal of Thoracic and Cardiovascular Surgery, 2006, 54 (9): : 396 - 398
[6] The clinical features, treatment, and prognosis of primary mediastinal malignant melanoma A case report
Li, ZiHai
Jia, Hui
Zhang, Baijiang
Zhang, Yongming
Li, Hui
Song, Pingping
[J]. MEDICINE, 2017, 96 (17)
[7] Primary Malignant Melanoma of the Mediastinum: Radiologic and Pathologic Correlation in Two Case
Park, Sun-Young
Kim, Mi Young
Chae, Eun Jin
[J]. KOREAN JOURNAL OF RADIOLOGY, 2012, 13 (06) : 823 - 826
[8] Anterior mediastinal tumors: Diagnostic accuracy of CT and MRI
Tomiyama, Noriyuki
Honda, Osamu
Tsubamoto, Mitsuko
Inoue, Atsuo
Sumikawa, Hiromitsu
Kuriyama, Keiko
Kusumoto, Masahiko
Johkoh, Takeshi
Nakamura, Hironobu
[J]. EUROPEAN JOURNAL OF RADIOLOGY, 2009, 69 (02) : 280 - 288
[9] Hepatocellular Carcinoma With Extrahepatic Metastasis Clinical Features and Prognostic Factors
Uchino, Koji
Tateishi, Ryosuke
Shiina, Shuichiro
Kanda, Miho
Masuzaki, Ryota
Kondo, Yuji
Goto, Tadashi
Omata, Masao
Yoshida, Haruhiko
Koike, Kazuhiko
[J]. CANCER, 2011, 117 (19) : 4475 - 4483
[10] Overall Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma
Wolchok, J. D.
Chiarion-Sileni, V.
Gonzalez, R.
Rutkowski, P.
Grob, J. -J.
Cowey, C. L.
Lao, C. D.
Wagstaff, J.
Schadendorf, D.
Ferrucci, P. F.
Smylie, M.
Dummer, R.
Hill, A.
Hogg, D.
Haanen, J.
Carlino, M. S.
Bechter, O.
Maio, M.
Marquez-Rodas, I.
Guidoboni, M.
McArthur, G.
Lebbe, C.
Ascierto, P. A.
Long, G. V.
Cebon, J.
Sosman, J.
Postow, M. A.
Callahan, M. K.
Walker, D.
Rollin, L.
Bhore, R.
Hodi, F. S.
Larkin, J.
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 2017, 377 (14) : 1345 - 1356

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