Subsets of ATP-sensitive potassium channel (KATP) inhibitors increase gap junctional intercellular communication in metastatic cancer cell lines independent of SUR expression

被引：9

作者：

Bodenstine, Thomas M. ^{[1
]}

Vaidya, Kedar S. ^{[1
]}

Ismail, Aimen ^{[1
]}

Beck, Benjamin H. ^{[1
]}

Diers, Anne R. ^{[1
]}

Edmonds, Mick D. ^{[1
]}

Kirsammer, Gina T. ^{[3
]}

Landar, Aimee ^{[1
]}

Welch, Danny R. ^{[1
,2
]}

机构：

[1] Univ Alabama, Dept Pathol, Birmingham, AL 35294 USA

[2] Univ Alabama, Ctr Comprehens Canc, Birmingham, AL 35294 USA

[3] Childrens Mem Res Ctr, Chicago, IL USA

来源：

FEBS LETTERS | 2012年 / 586卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Sulfonylurea; K-ATP; Gap junction; Glibenclamide; C6; GLIOMA-CELLS; BETA-CELL; GROWTH-INHIBITION; PROLIFERATION; PHOSPHORYLATION; PERMEABILITY; TRANSFECTION; CONNEXIN-43; TOLBUTAMIDE;

D O I：

10.1016/j.febslet.2011.11.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Gap junctional intercellular communication (GJIC) regulates cellular homeostasis by propagating signaling molecules, exchanging cellular metabolites, and coupling electrical signals. In cancer, cells exhibit altered rates of GJIC which may play a role in neoplastic progression. KATP channels help maintain membrane polarity and linkages between KATP channel activity and rates of GJIC have been established. The mechanistic relationship has not been fully elucidated. We report the effects of treatment with multiple KATP antagonist compounds on GJIC in metastatic cell lines demonstrating an increase in communication rates following treatment with compounds possessing specificities towards the SUR2 subunit of KATP. These effects remained consistent using cell lines with different expression levels of SUR1 and SUR2, suggesting possible off target effects on GJIC by these compounds. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：27 / 31

页数：5

共 35 条

[31] Saunders MM, 2001, CANCER RES, V61, P1765
[32] Glimepiride block of cloned ß-cell, cardiac and smooth muscle KATP channels
Song, DK
Ashcroft, FM
[J]. BRITISH JOURNAL OF PHARMACOLOGY, 2001, 133 (01) : 193 - 199
[33] Velasco A, 2000, J NEUROCHEM, V74, P1249
[34] Inhibition of astrocyte gap junctional communication by ATP depletion is reversed by calcium sequestration
Vera, B
SanchezAbarca, LI
Bolanos, JP
Medina, JM
[J]. FEBS LETTERS, 1996, 392 (03) : 225 - 228
[35] TRANSFECTION OF C6 GLIOMA-CELLS WITH CONNEXIN-43 CDNA - ANALYSIS OF EXPRESSION, INTERCELLULAR COUPLING, AND CELL-PROLIFERATION
ZHU, D
CAVENEY, S
KIDDER, GM
NAUS, CCG
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (05) : 1883 - 1887

← 1 2 3 4 →