Synthesis and SAR of highly selective MMP-13 inhibitors

被引：62

作者：

Li, JC

Rush, TS

Li, W

DeVincentis, D

Du, XM

Hu, YH

Thomason, JR

Xiang, JS

Skotnicki, JS

Tam, S

Cunningham, KM

Chockalingam, PS

Morris, EA

Levin, JI

机构：

[1] Wyeth Res, Dept Chem & Screening Sci, Cambridge, MA 02140 USA

[2] Wyeth Res, Dept Womens Hlth & Bone, Cambridge, MA 02140 USA

[3] Wyeth Res, Dept Chem & Screening Sci, Pearl River, NY 10965 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 22期

关键词：

D O I：

10.1016/j.bmcl.2005.08.001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described. (c) 2005 Elsevier Ltd. All rights reserved.

引用

收藏

页码：4961 / 4966

页数：6

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