Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review

被引：41

作者：

Plumb, RS ^{[1
]}

Dear, GJ ^{[1
]}

Mallett, DN ^{[1
]}

Higton, DM ^{[1
]}

Pleasance, S ^{[1
]}

Biddlecombe, RA ^{[1
]}

机构：

[1] GlaxoWellcome R&D, Dept Bioanal & Drug Metab, Ware SG12 0DP, Herts, England

来源：

XENOBIOTICA | 2001年 / 31卷 / 8-9期

关键词：

D O I：

10.1080/00498250110060941

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging technologies such as monolithic column chromatography and miniaturized chip-based systems are discussed.

引用

页码：599 / 617

页数：19

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