Interleukin-18 and diabetic nephropathy: A review

被引：96

作者：

Yaribeygi, Habib ^{[1
]}

Atkin, Stephen L. ^{[2
]}

Sahebkar, Amirhossein ^{[3
,4
,5
]}

机构：

[1] Shahid Beheshti Univ Med Sci, Chron Kidney Dis Res Ctr, Tehran, Iran

[2] Weill Cornell Med Qatar, Doha, Qatar

[3] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

[4] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[5] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 05期

关键词：

apoptosis; diabetic nephropathy; inflammatory response; interleukin-18; oxidative stress; tumor necrosis factor-alpha; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; INTERCELLULAR-ADHESION MOLECULE-1; ISOLATED RAT GLOMERULI; TNF-ALPHA PRODUCTION; GROWTH-FACTOR-BETA; IFN-GAMMA; FAS LIGAND; TGF-BETA; SIGNAL-TRANSDUCTION;

D O I：

10.1002/jcp.27427

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The inflammatory response has an important role in the pathophysiology of diabetic nephropathy that is contributed to by inflammatory mediators such as interleukin-1 (IL-1), IL-6, IL-18, tumor necrosis factor-alpha, and macrophage chemotactic protein-1; however, the role of IL-18 seems to be more specific than other cytokines in the inflammatory process. IL-18 is expressed in renal tissue and is upregulated by several stimuli including hyperglycemia. The expression/urinary level of IL-18 is positively correlated with the progression of diabetic nephropathy and the urinary albumin excretion rate. In this review, we have focused on the molecular pathways modulating the relationship between IL-18 and diabetic nephropathy.

引用

页码：5674 / 5682

页数：9