The stats of cancer - New molecular targets come of age

被引：1979

作者：

Yu, H ^{[1
]}

Jove, R

机构：

[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Program Immunol, Tampa, FL 33612 USA

[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Mol Oncol Program, Tampa, FL 33612 USA

[3] Univ S Florida, Coll Med, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 02期

关键词：

D O I：

10.1038/nrc1275

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance. STAT proteins - especially STAT3 and STAT5 - regulate all of these processes and are persistently activated in a surprisingly large number of human cancers. Consequently, STAT proteins are emerging - unexpectedly - as ideal targets for cancer therapy.

引用

页码：97 / 105

页数：9

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