The stats of cancer - New molecular targets come of age

被引：1979
作者：
Yu, H [1 ]
Jove, R
机构：
[1] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Program Immunol, Tampa, FL 33612 USA
[2] Univ S Florida, Coll Med, H Lee Moffitt Canc Ctr & Res Inst, Mol Oncol Program, Tampa, FL 33612 USA
[3] Univ S Florida, Coll Med, Dept Interdisciplinary Oncol, Tampa, FL 33612 USA
来源：
NATURE REVIEWS CANCER | 2004年 / 4卷 / 02期
关键词：
D O I：
10.1038/nrc1275
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance. STAT proteins - especially STAT3 and STAT5 - regulate all of these processes and are persistently activated in a surprisingly large number of human cancers. Consequently, STAT proteins are emerging - unexpectedly - as ideal targets for cancer therapy.
引用
收藏
页码：97 / 105
页数：9
相关论文
共 128 条
[1]   Roles of STAT3 defined by tissue-specific gene targeting [J].
Akira, S .
ONCOGENE, 2000, 19 (21) :2607-2611
[2]   Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma [J].
Aoki, Y ;
Feldman, GM ;
Tosato, G .
BLOOD, 2003, 101 (04) :1535-1542
[3]   VEGF differentially activates STAT3 in microvascular endothelial cells [J].
Bartoli, M ;
Platt, DH ;
Lemtalsi, T ;
Gu, XL ;
Brooks, SE ;
Marrero, MB ;
Caldwell, RB .
FASEB JOURNAL, 2003, 17 (09) :1562-+
[4]  
Battle T. E., 2002, Current Molecular Medicine (Hilversum), V2, P381, DOI 10.2174/1566524023362456
[5]   Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts [J].
Berg, T ;
Cohen, SB ;
Desharnais, J ;
Sonderegger, C ;
Maslyar, DJ ;
Goldberg, J ;
Boger, DL ;
Vogt, PK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (06) :3830-3835
[6]   THE MOLECULAR-GENETICS OF CANCER [J].
BISHOP, JM .
SCIENCE, 1987, 235 (4786) :305-311
[7]  
Blaskovich MA, 2003, CANCER RES, V63, P1270
[8]   Oncogenic kinase signalling [J].
Blume-Jensen, P ;
Hunter, T .
NATURE, 2001, 411 (6835) :355-365
[9]   Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis [J].
Bowman, T ;
Broome, MA ;
Sinibaldi, D ;
Wharton, W ;
Pledger, WJ ;
Sedivy, JM ;
Irby, R ;
Yeatman, T ;
Courtneidge, SA ;
Jove, R .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (13) :7319-7324
[10]   STATs in oncogenesis [J].
Bowman, T ;
Garcia, R ;
Turkson, J ;
Jove, R .
ONCOGENE, 2000, 19 (21) :2474-2488
12345678910