Organometallic Ruthenium Nitrosyl Obtained by C-H Bond Activation - Photoinduced Delivery of Nitric Oxide and NO-Mediated Antiproliferation Activity Studies

被引：16

作者：

Kumar, Rajan ^{[1
]}

Yadav, Anjlika ^{[2
]}

Ratnam, Anand ^{[1
]}

Kumar, Sushil ^{[1
]}

Bala, Manju ^{[1
]}

Sur, Debpali ^{[2
]}

Narang, Shikha ^{[1
]}

Singh, Udai P. ^{[1
]}

Mandal, Prabhat K. ^{[2
]}

Ghosh, Kaushik ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Roorkee 247667, Uttar Pradesh, India

[2] Indian Inst Technol, Dept Biotechnol, Roorkee 247667, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2017年 / 45期

关键词：

Ruthenium; Nitrosyl complexes; Structure elucidation; Photochemistry; Antiproliferative activity; COORDINATED NO; VISIBLE-LIGHT; METAL NITROSYLS; TRANSFER HYDROGENATION; PHOTOLABILE RUTHENIUM; BIOLOGICAL-ACTIVITY; AQUEOUS-SOLUTION; SCHIFF-BASES; !text type='JS']JS[!/text]-K; COMPLEXES;

D O I：

10.1002/ejic.201700839

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The azo dye methyl red, which has carboxylato and azo functional groups, was used as a ligand for the synthesis of the cyclometalated Ru-III complex [Ru(L-1)(PPh3)(2)Cl] (1, (LH2)-H-1 = 2-{[4-(dimethylamino)phenyl]diazenyl}benzoic acid) through C-H bond activation. Complex 1 was treated with nitric oxide to afford the organometallic ruthenium nitrosyl complex [Ru((LH)-H-2)(PPh3)(2)(NO)Cl][ClO4] (1a, (LH)-H-2 = 2-{[4-(dimethylamino)-3-nitrophenyl]diazenyl}benzoic acid). The molecular structures of 1CH(3)OH and 1aCH(3)OH were determined by X-ray crystallography. The diamagnetic complex 1a with S = 0 ground state was studied by H-1 and P-31 NMR spectroscopy. In the nitrosyl complex, the coordinated NO is photolabile under UV and visible light, and the liberated NO was trapped by reduced myoglobin. The NO, photoreleased under visible light, was utilized in antiproliferation activity studies on human (A549, HEK293T, and HeLa) and mouse (NIH3T3) cancer cell lines.

引用

页码：5334 / 5343

页数：10