Malignant lymphoma associated with rheumatoid arthritis, developing shortly after initiation of oral methotrexate

被引：7

作者：

Gono, T

Shimojima, Y

Hoshi, K

Yamamoto, K

Tokuda, T

Shikama, N

Matsuda, M

Ikeda, S

机构：

[1] Shinshu Univ, Sch Med, Dept Med 3, Matsumoto, Nagano 3908621, Japan

[2] Shinshu Univ, Sch Med, Dept Radiol, Matsumoto, Nagano 3908621, Japan

来源：

INTERNAL MEDICINE | 2004年 / 43卷 / 02期

关键词：

rheumatoid arthritis; malignant lymphoma; methotrexate; CHOP therapy; Epstein-Barr virus; magnetic resonance imaging;

D O I：

10.2169/internalmedicine.43.135

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a patient with rheumatoid arthritis (RA) who developed malignant lymphoma of the diffuse large B-cell type in the right submandibular region shortly after initiation of oral methotrexate (MTX). Despite cessation of MTX, the lymphadenopathy did not regress, and only reached complete remission after 3 courses of CHOP therapy followed by irradiation. In this patient highly active RA itself was considered to be the main cause of malignant lymphoma, and MTX might have contributed to the development by modifying the immune system. When RA is highly active, MTX should be used carefully because of the possible development of malignant lymphoma as well as other serious complications.

引用

页码：135 / 138

页数：4

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