Autochthonous mouse models for prostate cancer: past, present and future

被引：64
作者：
Huss, WJ
Maddison, LA
Greenberg, NM
机构：
[1] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA
[2] Baylor Coll Med, Scott Dept Urol, Houston, TX 77030 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2001年 / 11卷 / 03期
关键词：
mouse models; prostate cancer; probasin; TRAMP; metastasis;
D O I：
10.1006/scbi.2001.0373
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Prostate cancer continues to be the second leading cancer related death among men. In order to more fully develop effective prevention and intervention strategies for this prevalent disease, the underlying molecular mechanisms of initiation, progression and metastatic spread must be understood. To this end mouse models have an essential role in prostate cancer research in that they can closely mimic the pathological and biochemical features of the disease. In this review we discuss the history of autochthonous murine models of prostate cancer, the essentials of the idealized mouse model for prostate cancer and speculate on approaches towards this goal.
引用
收藏
页码：245 / 259
页数：15
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