The Genetics of Pemphigus

被引：60
作者：
Sinha, Animesh A. [1 ,2 ]
机构：
[1] SUNY Buffalo, Dept Dermatol, Buffalo, NY 14263 USA
[2] Roswell Pk Canc Inst, Buffalo, NY 14263 USA
来源：
DERMATOLOGIC CLINICS | 2011年 / 29卷 / 03期
关键词：
Genetics; Pemphigus; Autoimmunity; Blistering disorders; CLASS-II; JEWISH PATIENTS; T-CELLS; ALOPECIA-AREATA; HLA-A; VULGARIS; DISEASE; SUSCEPTIBILITY; GENES; ASSOCIATION;
D O I：
10.1016/j.det.2011.03.020
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Pemphigus vulgaris (PV) is an autoimmune blistering disorder with a complex etiology involving an interplay of genetic as well as environmental factors, most of which remain unknown. Despite the identification of several human leukocyte antigen (HLA) alleles as risk factors for disease, no other non-HLA genes have clearly been implicated in disease susceptibility. Newer candidate gene and whole-genome approaches are needed to illuminate the full palate of genetic risk elements in PV. Based on this information, genetic-based tools can be expected to provide a scientific rationale for future clinical decision-making by physicians and facilitate an era of personalized medicine.
引用
收藏
页码：381 / +
页数：12
相关论文
共 70 条
[1]   MAJOR HISTOCOMPATIBILITY COMPLEX HAPLOTYPE STUDIES IN ASHKENAZI JEWISH PATIENTS WITH PEMPHIGUS-VULGARIS [J].
AHMED, AR ;
YUNIS, EJ ;
KHATRI, K ;
WAGNER, R ;
NOTANI, G ;
AWDEH, Z ;
ALPER, CA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (19) :7658-7662
[2]   MAJOR HISTOCOMPATIBILITY COMPLEX HAPLOTYPES AND CLASS-II GENES IN NON-JEWISH PATIENTS WITH PEMPHIGUS VULGARIS [J].
AHMED, AR ;
WAGNER, R ;
KHATRI, K ;
NOTANI, G ;
AWDEH, Z ;
ALPER, CA ;
YUNIS, EJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (11) :5056-5060
[3]   The clinical phenotype of pemphigus is defined by the anti-desmoglein autoantibody profile [J].
Amagai, M ;
Tsunoda, K ;
Zillikens, D ;
Nagai, T ;
Nishikawa, T .
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1999, 40 (02) :167-170
[4]   INDUCTION OF PEMPHIGUS IN NEONATAL MICE BY PASSIVE TRANSFER OF IGG FROM PATIENTS WITH THE DISEASE [J].
ANHALT, GJ ;
LABIB, RS ;
VOORHEES, JJ ;
BEALS, TF ;
DIAZ, LA .
NEW ENGLAND JOURNAL OF MEDICINE, 1982, 306 (20) :1189-1196
[5]  
Asilian Ali, 2006, Skinmed, V5, P69
[6]   Multiplex family-based study in systemic lupus erythematosus:: association between the R620W polymorphism of PTPN22 and the FcγRIIa (CD32A) R131 allele [J].
Balada, E. ;
Villarreal-Tolchinsky, J. ;
Ordi-Ros, J. ;
Labrador, M. ;
Serrano-Acedo, S. ;
Martinez-Lostao, L. ;
Vilardell-Tarres, M. .
TISSUE ANTIGENS, 2006, 68 (05) :432-438
[7]   PEMPHIGUS-VULGARIS AND PEMPHIGUS-VEGETANS [J].
BECKER, BA ;
GASPARI, AA .
DERMATOLOGIC CLINICS, 1993, 11 (03) :429-452
[8]  
Bhanusali D, 2008, J INVEST DERMATOL, V128, P86
[9]   HLA-class 1 and class 2 antigens in Turkish patients with pemphigus [J].
Birol, A ;
Anadolu, RY ;
Tutkak, H ;
Gürgey, E .
INTERNATIONAL JOURNAL OF DERMATOLOGY, 2002, 41 (02) :79-83
[10]   Genetic dissection of transcriptional regulation in budding yeast [J].
Brem, RB ;
Yvert, G ;
Clinton, R ;
Kruglyak, L .
SCIENCE, 2002, 296 (5568) :752-755
1234567