Epidemiology and genetic risk of type 1 diabetes among children in Aragon community, Spain

被引：5

作者：

Soria, Jesus

Garagorri, Jesus M. ^{[1
]}

Rodriguez, Mercedes ^{[2
]}

Rodriguez, Gerardo ^{[1
]}

Larrad, Luis ^{[3
]}

Elizalde, Mercedes

机构：

[1] Lozano Blesa Univ Clin Hosp, Unit Paediat Endocrinol, Zaragoza, Spain

[2] Miguel Servet Univ Childrens Hosp, Diabet Care Unit, Zaragoza, Spain

[3] Lozano Blesa Univ Clin Hosp, Unit Immunol & Genet, Zaragoza, Spain

来源：

DIABETES RESEARCH AND CLINICAL PRACTICE | 2008年 / 79卷 / 01期

关键词：

epidemiology; annual incidence; genetic risk; type; 1; diabetes; children;

D O I：

10.1016/j.diabres.2007.06.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The incidence of type 1 diabetes in children from Aragon (a population of the North of Spain) is reported determining the relations between the onset of type 1 diabetes and gender, age at diagnosis, genetic risk (HLA class II genes) or climatology factors. The population at risk was all 0-14 year-old inhabitants. Patients were identified from five sources: hospitals, primary assistance, endocrinologists, diabetic associations and diabetes camps. The degree of ascertainment was 98.93%. HLA genetic study was performed. Annual incidence was 16.4 per 100,000 per year (95% CI: 14.7-18.2). This incidence was significantly higher in males than in females, 18.7 versus 14.2 (p < 0.02), and increased with age. The haplotypes (DR3)-DQB1*0201/(DR4)-DQB1*0302 and (DR3)-DQB1*0201/(DR7)-DQB1*0202 conferred the highest risk of type 1 diabetes. A relative high incidence of type 1 diabetes mellitus has been demonstrated in the Northeast of Spain, and it does not support south-to-north incidence gradient in Europe. Haplotypes that conferred a higher risk of disease agree with those founded in other Caucasic populations. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：112 / 116

页数：5

共 36 条

[1] Spatiotemporal trends and age-period-cohort modeling of the incidence of type 1 diabetes among children aged <15 years in Norway 1973-1982 and 1989-2003 [J].

Aamodt, Geir ;

Stene, Lars C. ;

Njolstad, Pal R. ;

Sovik, Oddmund ;

Joner, Geir .

DIABETES CARE, 2007, 30 (04) :884-889

[2] Incidence and trends of childhood Type 1 diabetes worldwide 1990-1999 [J].

Bessaoud, K. ;

Boudraa, G. ;

Molinero de Ropolo, M. ;

de Sereday, M. ;

Marti, M. L. ;

Moser, M. ;

Lapertosa, S. ;

Damiano, M. ;

Verge, C. ;

Howard, N. ;

Schober, E. ;

Jordan, O. ;

Weets, I. ;

Gorus, F. ;

Coeckelberghs, M. ;

Rooman, R. ;

Van Gaal, L. ;

Franco, L. J. ;

Ferreira, S. R. G. ;

Lisboa, H. P. K. ;

Kurtz, L. A. ;

Graebin, R. ;

Kutzke, L. ;

Rodriges, C. ;

Savova, R. ;

Christov, V. ;

Iotova, V. ;

Tzaneva, V. ;

Pacaud, D. ;

Toth, E. ;

Tan, M. H. ;

Carrasco, E. ;

Perez, F. ;

Ze, Y. ;

Bo, Y. ;

Chen, S. ;

Fu, L. ;

Deng, L. ;

Shen, S. ;

Teng, K. ;

Wang, C. ;

Jian, H. ;

Ju, J. ;

Yan, C. ;

Ze, Y. ;

Deng, Y. ;

Li, C. ;

Zhang, Y. ;

Liu, Y. ;

Long, X. .

DIABETIC MEDICINE, 2006, 23 (08) :857-866

[3]

BODMER JG, 1995, TISSUE ANTIGENS, V46, P1

[4] Secular trends, disease maps and ecological analyses of the incidence of childhood onset type 1 diabetes in Northern Ireland, 1989-2003 [J].

Cardwell, C. R. ;

Carson, D. J. ;

Patterson, C. C. .

DIABETIC MEDICINE, 2007, 24 (03) :289-295

[5] Incidence data of childhood-onset type I diabetes in France during 1988-1997:: The case for a shift toward younger age at onset [J].

Charkaluk, ML ;

Czernichow, P ;

Lévy-Marchal, C .

PEDIATRIC RESEARCH, 2002, 52 (06) :859-862

[6] Incidence of type I diabetes mellitus in Navarre, Spain (1975-91) [J].

Chueca, M ;

Oyarzabal, M ;

Reparaz, F ;

Garagorri, JM ;

Sola, A .

ACTA PAEDIATRICA, 1997, 86 (06) :632-637

[7]

Domínguez AC, 2000, REV CLIN ESP, V200, P257

[8] HLA class II immunogenetics and incidence of insulin-dependent diabetes mellitus in the population of Cantabria (Northern Spain) [J].

Escribano-de-Diego, J ;

Sánchez-Velasco, P ;

Luzuriaga, C ;

Ocejo-Vinyals, JG ;

Paz-Miguel, JE ;

Leyva-Cobián, F .

HUMAN IMMUNOLOGY, 1999, 60 (10) :990-1000

[9] The rise of childhood type 1 diabetes in the 20th century [J].

Gale, EAM .

DIABETES, 2002, 51 (12) :3353-3361

[10] Rising incidence of insulin dependent diabetes in children aged under 5 years in the Oxford region: time trend analysis [J].

Gardner, SG ;

Bingley, PJ ;

Sawtell, PA ;

Weeks, S ;

Gale, EAM ;

Bell, RAF ;

Dunger, DB ;

Mukhtar, A ;

OMalley, BP ;

Silk, BR ;

Smith, EH ;

Scott, RDM ;

Latham, PJ ;

Lakhani, PK ;

Paton, RC ;

Ackland, FM ;

Fox, CJ ;

Griffin, NK ;

Matthews, DR ;

Neil, HAW ;

Mann, NP ;

Simpson, HCR ;

Brown, RS ;

Knight, AH ;

Cowen, JM ;

Pearce, JC ;

Cheetham, CH ;

Gallen, IW ;

Sandler, L ;

Westcott, T .

BRITISH MEDICAL JOURNAL, 1997, 315 (7110) :713-717

← 1 2 3 4 →