Epidrugs in Amyotrophic Lateral Sclerosis/Frontotemporal Dementia: Contextualizing a Role for Histone Kinase Inhibition in Neurodegenerative Disease

被引：9

作者：

Cobos, Samantha N. ^{[1
,2
]}

Torrente, Mariana P. ^{[1
,2
,3
,4
]}

机构：

[1] Brooklyn Coll, Chem Dept, Brooklyn, NY 11210 USA

[2] CUNY, Grad Ctr, PhD Program Chem, New York, NY 10016 USA

[3] CUNY, Grad Ctr, PhD Program Biochem, New York, NY 10016 USA

[4] CUNY, Grad Ctr, PhD Program Biol, New York, NY 10016 USA

来源：

ACS PHARMACOLOGY & TRANSLATIONAL SCIENCE | 2022年 / 5卷 / 02期

关键词：

AURORA-B; PROTEIN-KINASE; CHROMATIN; PHOSPHORYLATION; TRICHOSTATIN; ACETYLATION; ACTIVATION; REVEALS; H3;

D O I：

10.1021/acsptsci.1c00265

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Breakthroughs in understanding the epigenetic mechanisms involved in neurodegenerative disease have highlighted "epidrugs" as a potential avenue for therapeutic development. Here, we expand on the future of epidrugs against neurodegeneration and discuss promising novel targets under-exploited thus far: histone kinases.

引用

页码：134 / 137

页数：4

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