Effect of partial and total sleep deprivation on serum testosterone in healthy males: a systematic review and meta-analysis

被引:13
作者
Su, Liang [1 ]
Zhang, Si-Zheng [1 ]
Zhu, Jian [1 ]
Wu, Jie [1 ]
Jiao, Yong-zheng [1 ]
机构
[1] China Acad Chinese Med Sci, Guanganmen Hosp, Beijing, Peoples R China
基金
中国国家自然科学基金;
关键词
Sleep; Sleep deprivation; Male; Testosterone; Meta-analysis; ASSOCIATION; DURATION; ADULTS; HETEROGENEITY; RESTRICTION; DISTURBANCE; DISORDERS; RESPONSES; HORMONES; QUALITY;
D O I
10.1016/j.sleep.2021.10.031
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Background: Currently, there is no consensus on the effect of sleep deprivation on male serum testosterone. This systematic review and meta-analysis aimed to determine the association between partial/ total sleep deprivation and male serum testosterone level. Methods: The literature related to sleep deprivation and male serum testosterone in the PubMed, Embase, and Cochrane Library databases were searched from their inception to July 15, 2021. Data were pooled using the Stata 15 software. The results were presented as standard mean differences (SMDs) with their 95% confidence intervals (CIs). Results: Eighteen studies involving 252 men were included in the systematic review and meta-analysis. The findings revealed that short-term partial sleep deprivation had no significant effect on male serum testosterone (SMD =-0.22; 95% CI:-0.5, 0.06; P = 0.13), while total sleep deprivation reduced the male testosterone levels (SMD =-0.64; 95% CI:-0.87,-0.42; P < 0.001). According to the intervention duration of total sleep deprivation, subgroup analysis was conducted by a fixed-effects model. The results revealed that the serum testosterone was significantly decreased after 24 h total sleep deprivation (SMD = 0.67; 95% CI = 0.93,-0.42, P < 0.001), as well as 40-48 h total sleep deprivation (SMD = 0.74; 95% CI = 1.22,-0.26, P = 0.002). Conclusions: This meta-analysis revealed that total sleep deprivation (more than or equal to 24 h) reduces the male testosterone levels, while short-term partial sleep deprivation has no significant effect on male serum testosterone. Sleep duration plays a pivotal role in maintaining male serum testosterone levels. (c) 2021 Elsevier B.V. All rights reserved.
引用
收藏
页码:267 / 273
页数:7
相关论文
共 62 条
  • [1] Effects of Partial Sleep Deprivation on Proinflammatory Cytokines, Growth Hormone, and Steroid Hormone Concentrations During Repeated Brief Sprint Interval Exercise
    Abedelmalek, Salma
    Souissi, Nizar
    Chtourou, Hamdi
    Denguezli, Meriam
    Aouichaoui, Chirine
    Ajina, Monia
    Aloui, Asma
    Dogui, Mohamed
    Haddouk, Samy
    Tabka, Zouhair
    [J]. CHRONOBIOLOGY INTERNATIONAL, 2013, 30 (04) : 502 - 509
  • [2] ADRENOCORTICAL AND GONADAL-STEROIDS DURING SLEEP-DEPRIVATION
    AKERSTEDT, T
    PALMBLAD, J
    DELATORRE, B
    MARANA, R
    GILLBERG, M
    [J]. SLEEP, 1980, 3 (01) : 23 - 30
  • [3] The effects of partial sleep deprivation on energy balance: a systematic review and meta-analysis
    Al Khatib, H. K.
    Harding, S. V.
    Darzi, J.
    Pot, G. K.
    [J]. EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2017, 71 (05) : 614 - 624
  • [4] Sleep disturbance in mental health problems and neurodegenerative disease
    Anderson, Kirstie N.
    Bradley, Andrew J.
    [J]. NATURE AND SCIENCE OF SLEEP, 2013, 5 : 61 - 75
  • [5] Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery
    Arnal, P. J.
    Drogou, C.
    Sauvet, F.
    Regnauld, J.
    Dispersyn, G.
    Faraut, B.
    Millet, G. Y.
    Leger, D.
    Gomez-Merino, D.
    Chennaoui, M.
    [J]. JOURNAL OF NEUROENDOCRINOLOGY, 2016, 28 (02) : 1 - 9
  • [6] Effects of acutely displaced sleep on testosterone
    Axelsson, J
    Ingre, M
    Åkerstedt, T
    Holmbäck, U
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (08) : 4530 - 4535
  • [7] Blumert PA, 2007, J STRENGTH COND RES, V21, P1146
  • [8] Circadian Variation in Salivary Testosterone Across Age Classes in Ache Amerindian Males of Paraguay
    Bribiescas, Richard G.
    Hill, Kim R.
    [J]. AMERICAN JOURNAL OF HUMAN BIOLOGY, 2010, 22 (02) : 216 - 220
  • [9] The impact of starchy food structure on postprandial glycemic response and appetite: a systematic review with meta-analysis of randomized crossover trials
    Cai, Mingzhu
    Dou, Bowen
    Pugh, Jennifer E.
    Lett, Aaron M.
    Frost, Gary S.
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2021, 114 (02) : 472 - 487
  • [10] Sympathetic neural responsiveness to sleep deprivation in older adults: sex differences
    Carter, Jason R.
    Fonkoue, Ida T.
    Greenlund, Ian M.
    Schwartz, Christopher E.
    Mokhlesi, Babak
    Smoot, Carl A.
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2019, 317 (02): : H315 - H322