Cortical complexity in world trade center responders with chronic posttraumatic stress disorder

被引:11
作者
Kritikos, Minos [1 ,2 ]
Clouston, Sean A. P. [1 ,2 ]
Huang, Chuan [3 ,4 ]
Pellecchia, Alison C. [5 ]
Mejia-Santiago, Stephanie [5 ]
Carr, Melissa A. [5 ]
Kotov, Roman [4 ]
Lucchini, Roberto G. [6 ]
Gandy, Samuel E. [7 ,8 ,9 ]
Bromet, Evelyn J. [4 ]
Luft, Benjamin J. [5 ,10 ]
机构
[1] SUNY Stony Brook, Renaissance Sch Med, Program Publ Hlth, Stony Brook, NY 11794 USA
[2] SUNY Stony Brook, Renaissance Sch Med, Dept Family Populat & Prevent Med, Stony Brook, NY 11794 USA
[3] Renaissance Sch Med Stony Brook, Dept Radiol, Stony Brook, NY USA
[4] SUNY Stony Brook, Renaissance Sch Med, Dept Psychiat, Stony Brook, NY 11794 USA
[5] SUNY Stony Brook, Renaissance Sch Med, World Trade Ctr Hlth & Wellness Program, Stony Brook, NY 11794 USA
[6] Florida Int Univ, Robert Stempel Sch Publ Hlth, Dept Environm Hlth Sci, Miami, FL 33199 USA
[7] Icahn Sch Med Mt Sinai, Dept Neurol, New York, NY 10029 USA
[8] Icahn Sch Med Mt Sinai, Dept Psychiat, New York, NY 10029 USA
[9] Icahn Sch Med Mt Sinai, Mt Sinai Alzheimers Dis Res Ctr, New York, NY 10029 USA
[10] SUNY Stony Brook, Renaissance Sch Med, Dept Med, Stony Brook, NY 11794 USA
关键词
FRACTAL DIMENSION ANALYSIS; WHITE-MATTER INTEGRITY; SOURCE-BASED MORPHOMETRY; INFERIOR FRONTAL GYRUS; CEREBRAL-CORTEX; GREY-MATTER; SEPTEMBER; 11; LIFE EVENTS; RISK-FACTOR; PTSD;
D O I
10.1038/s41398-021-01719-7
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Approximately 23% of World Trade Center (WTC) responders are experiencing chronic posttraumatic stress disorder (PTSD) associated with their exposures at the WTC following the terrorist attacks of 9/11/2001, which has been demonstrated to be a risk factor for cognitive impairment raising concerns regarding their brain health. Cortical complexity, as measured by analyzing Fractal Dimension (FD) from T-1 MRI brain images, has been reported to be reduced in a variety of psychiatric and neurological conditions. In this report, we hypothesized that FD would be also reduced in a case-control sample of 99 WTC responders as a result of WTC-related PTSD. The results of our surface-based morphometry cluster analysis found alterations in vertex clusters of complexity in WTC responders with PTSD, with marked reductions in regions within the frontal, parietal, and temporal cortices, in addition to whole-brain absolute bilateral and unilateral complexity. Furthermore, region of interest analysis identified that the magnitude of changes in regional FD severity was associated with increased PTSD symptoms (reexperiencing, avoidance, hyperarousal, negative affect) severity. This study confirms prior findings on FD and psychiatric disorders and extends our understanding of FD associations with posttraumatic symptom severity. The complex and traumatic experiences that led to WTC-related PTSD were associated with reductions in cortical complexity. Future work is needed to determine whether reduced cortical complexity arose prior to, or concurrently with, onset of PTSD.
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页数:10
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