Signalling for survival and death in neurones - The role of stress-activated kinases, JNK and p38

被引：268
作者：
Harper, SJ
LoGrasso, P
机构：
[1] Merck Sharp & Dohme Res Labs, Dept Pharmacol, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England
[2] MRL San Diego, Dept Neuroinflammat, La Jolla, CA 92037 USA
来源：
CELLULAR SIGNALLING | 2001年 / 13卷 / 05期
关键词：
JNK; p38; CEP1347; neurone; cell death; kinase;
D O I：
10.1016/S0898-6568(01)00148-6
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The pathways involved in neuronal survival or death have been extensively studied mainly in cell lines. Recent evidence has suggested that activation of the stress activated pathways, jun N-terminal kinase (JNK) and p38 may play important roles in neuronal cell death or regeneration. In this review we will discuss these pathways in detail. We will examine the evidence that these pathways are important in neuronal cell death. Finally we will review the evidence that inhibitors of these pathways have a neuroprotective effect both in vitro and in vivo. (C) 2001 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：299 / 310
页数：12
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