Regulation of ion channels by phosphatidylinositol 4,5-bisphosphate

被引：369

作者：

Suh, BC ^{[1
]}

Hille, B ^{[1
]}

机构：

[1] Univ Washington, Sch Med, Dept Physiol & Biophys, Seattle, WA 98195 USA

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2005年 / 15卷 / 03期

关键词：

D O I：

10.1016/j.conb.2005.05.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Phosphaticlylinositol 4,5-bisphosphate is a signaling phospholipid of the plasma membrane that has a dynamically changing concentration. In addition to being the precursor of inositol trisphosphate and diacylglycerol, it complexes with and regulates many cytoplasmic and membrane proteins. Recent work has characterized the regulation of a wide range of ion channels by phosphatidylinositol 4,5-bisphosphate, helping to redefine the role of this lipid in cells and in neurobiology. In most cases, phosphaticlylinositol 4,5bisphosphate increases channel activity, and its hydrolysis by phospholipase C reduces channel activity.

引用

页码：370 / 378

页数：9

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