Psychiatric Disease Susceptibility and Pain in Chronic Pancreatitis: Association or Causation?

被引：3

作者：

Faghih, Mahya ^{[1
,2
]}

Drewes, Asbjorn M. ^{[3
,4
]}

Singh, Vikesh K. ^{[1
,2
]}

机构：

[1] Johns Hopkins Med Inst, Pancreatitis Ctr, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Div Gastroenterol, Baltimore, MD 21205 USA

[3] Aalborg Univ Hosp, Dept Gastroenterol & Hepatol, Ctr Pancreat Dis & Mech Sense, Aalborg, Denmark

[4] Aalborg Univ Hosp, Dept Clin Med, Aalborg, Denmark

来源：

AMERICAN JOURNAL OF GASTROENTEROLOGY | 2021年 / 116卷 / 10期

关键词：

D O I：

10.14309/ajg.0000000000001491

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Pain perception in chronic pancreatitis (CP) is governed by the transmission of nociceptive inputs into the pain processing centers of the brain. These regions of the brain overlap with those that regulate and process emotions and cognition. Disorders in these regions also result in psychiatric conditions such as depression, anxiety, and posttraumatic stress disorder. The present study by Dunbar et al. evaluated 24 single nucleotide polymorphisms associated with anxiety and/or posttraumatic stress disorder and found correlations with constant and severe pain phenotypes in CP patients from a large cross-sectional cohort study. Although causation cannot be proven, the findings suggest that there may be a role for neuromodulator drugs for the treatment of pain in CP based on individual genetic susceptibility.

引用

页码：2026 / 2028

页数：3

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