Spiculoic acids A and B, new polyketides isolated from the Caribbean marine sponge Plakortis angulospiculatusi

被引：36
作者：
Huang, XH
van Soest, R
Roberge, M
Andersen, RJ
机构：
[1] Univ British Columbia, Dept Chem, Vancouver, BC V6T 1Z1, Canada
[2] Univ British Columbia, Dept Earth & Ocean Sci, Vancouver, BC V6T 1Z1, Canada
[3] Univ British Columbia, Dept Biochem & Mol Biol, Vancouver, BC V6T 1Z1, Canada
[4] Univ Amsterdam, Zool Museum, NL-1012 WX Amsterdam, Netherlands
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 01期
关键词：
D O I：
10.1021/ol0361047
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two novel polyketides, spiculoic acids A (1) and B (2), have been isolated from extracts of the Caribbean marine sponge Plakortis angulospiculatus. The structures of 1 and 2 were elucidated by detailed analysis of spectroscopic data. Spiculoic acid A (1) showed in vitro cytotoxicity against human breast cancer MCF-7 cells. It has a putative polyketide biogenetic origin that involves incorporation of four butyrate units and a Diels Alderase catalyzed intramolecular [4 + 2] cycloaddition reaction.
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页码：75 / 78
页数：4
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