Extracellular vesicles derived from gut microbiota in inflammatory bowel disease and colorectal cancer

被引：9

作者：

Alberti, Giusi ^{[1
]}

Mazzola, Margherita ^{[1
]}

Gagliardo, Carola ^{[2
]}

Pitruzzella, Alessandro ^{[1
]}

Fucarini, Alberto ^{[1
]}

Giammanco, Marco ^{[3
]}

Tomasello, Giovanni ^{[1
]}

Carini, Francesco ^{[1
]}

机构：

[1] Univ Hosp Policlin Paolo Giaccone Palermo, Inst Human Anat & Histol, Dept Biomed Neurosci & Adv Diagnost, BIND, Palermo, Italy

[2] Dept Hlth Promot Mother & Child Care Internal Med, Palermo, Italy

[3] Univ Hosp Policlin Paolo Giaccone Palermo, Dept Surg Oncol & Stomatol Sci DiChirOnS, Palermo, Italy

来源：

BIOMEDICAL PAPERS-OLOMOUC | 2021年 / 165卷 / 03期

关键词：

extracellular vesicles; gut microbiota; inflammatory bowel disease; colorectal cancer; OUTER-MEMBRANE VESICLES; HEAT-SHOCK PROTEINS; OXIDATIVE STRESS; EPITHELIAL-CELLS; BIOGENESIS; BACTERIA; DNA; DIVERSITY; SECRETION; PROMOTES;

D O I：

10.5507/bp.2021.042

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The human gut microbiome encompasses inter alia, the myriad bacterial species that create the optimal host -microorganism balance essential for normal metabolic and immune function. Various lines of evidence suggest that dysregulation of the microbiota-host interaction is linked to pathologies such as inflammatory bowel disease (IBD) and colorectal cancer (CRC). Extracellular vesicles (EVs), found in virtually all body fluids and produced by both eukaryotic cells and bacteria are involved in cell-cell communication and crosstalk mechanisms, such as the immune response, barrier function and intestinal flora. This review highlights advancements in knowledge of the functional role that EVs may have in IBD and CRC, and discusses the possible use of EVs derived from intestinal microbiota in therapeutic strategies for treating these conditions.

引用

页码：233 / 240

页数：8

共 93 条

[61] Immunization with Salmonella enterica Serovar Typhimurium-Derived Outer Membrane Vesicles Delivering the Pneumococcal Protein PspA Confers Protection against Challenge with Streptococcus pneumoniae [J].

Muralinath, Maneesha ;

Kuehn, Meta J. ;

Roland, Kenneth L. ;

Curtiss, Roy, III .

INFECTION AND IMMUNITY, 2011, 79 (02) :887-894

[62] Circulating Exosomal microRNAs as Biomarkers of Colon Cancer [J].

Ogata-Kawata, Hiroko ;

Izumiya, Masashi ;

Kurioka, Daisuke ;

Honma, Yoshitaka ;

Yamada, Yasuhide ;

Furuta, Koh ;

Gunji, Toshiaki ;

Ohta, Hideki ;

Okamoto, Hiroyuki ;

Sonoda, Hikaru ;

Watanabe, Masatoshi ;

Nakagama, Hitoshi ;

Yokota, Jun ;

Kohno, Takashi ;

Tsuchiya, Naoto .

PLOS ONE, 2014, 9 (04)

[63] Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study [J].

Petousis-Harris, Helen ;

Paynter, Janine ;

Morgan, Jane ;

Saxton, Peter ;

McArdle, Barbara ;

Goodyear-Smith, Felicity ;

Black, Steven .

LANCET, 2017, 390 (10102) :1603-1610

[64] Effect of colorectal cancer-derived extracellular vesicles on the immunophenotype and cytokine secretion profile of monocytes and macrophages [J].

Popena, Ineta ;

Abols, Arturs ;

Saulite, Liga ;

Pleiko, Karlis ;

Zandberga, Elina ;

Jekabsons, Kaspars ;

Endzelins, Edgars ;

Llorente, Alicia ;

Line, Aija ;

Riekstina, Una .

CELL COMMUNICATION AND SIGNALING, 2018, 16

[65] The Pancreatic Cancer Microbiome Promotes Oncogenesis by Induction of Innate and Adaptive Immune Suppression [J].

Pushalkar, Smruti ;

Hundeyin, Mautin ;

Daley, Donnele ;

Zambirinis, Constantinos P. ;

Kurz, Emma ;

Mishra, Ankita ;

Mohan, Navyatha ;

Aykut, Berk ;

Usyk, Mykhaylo ;

Torres, Luisana E. ;

Werba, Gregor ;

Zhang, Kevin ;

Guo, Yuqi ;

Li, Qianhao ;

Akkad, Neha ;

Lall, Sarah ;

Wadowski, Benjamin ;

Gutierrez, Johana ;

Rossi, Juan Andres Kochen ;

Herzog, Jeremy W. ;

Diskin, Brian ;

Torres-Hernandez, Alejandro ;

Leinwand, Josh ;

Wang, Wei ;

Taunk, Pardeep S. ;

Savadkar, Shivraj ;

Janal, Malvin ;

Saxena, Anjana ;

Li, Xin ;

Cohen, Deirdre ;

Sartor, R. Balfour ;

Saxena, Deepak ;

Miller, George .

CANCER DISCOVERY, 2018, 8 (04) :403-416

[66] Mechanisms of Disease: Inflammatory Bowel Diseases [J].

Ramos, Guilherme Piovezani ;

Papadakis, Konstantinos A. .

MAYO CLINIC PROCEEDINGS, 2019, 94 (01) :155-165

[67] Linking Gut Microbiota to Colorectal Cancer [J].

Raskov, Hans ;

Burcharth, Jakob ;

Pommergaard, Hans-Christian .

JOURNAL OF CANCER, 2017, 8 (17) :3378-3395

[68] The Potential of HLA-G-Bearing Extracellular Vesicles as a Future Element in HLA-G Immune Biology [J].

Rebmann, Vera ;

Konig, Lisa ;

Nardi, Fabiola da Silva ;

Wagner, Bettina ;

Santos Manvailer, Luis Felipe ;

Horn, Peter A. .

FRONTIERS IN IMMUNOLOGY, 2016, 7

[69] Extracellular small heat shock proteins: exosomal biogenesis and function [J].

Reddy, V. Sudhakar ;

Madala, Satish K. ;

Trinath, Jamma ;

Reddy, G. Bhanuprakash .

CELL STRESS & CHAPERONES, 2018, 23 (03) :441-454

[70] DNA-containing membrane vesicles of Pseudomonas aeruginosa PAO1 and their genetic transformation potential [J].

Renelli, M ;

Matias, V ;

Lo, RY ;

Beveridge, TJ .

MICROBIOLOGY-SGM, 2004, 150 :2161-2169

← 1 2 3 4 5 6 7 8 9 10 →