Design of an antibiotic delivery system based on a bioresorbable bone substitute

被引：3
|
作者：
Vogt, Sebastian [2 ]
Schnabelrouch, Matthias [1 ]
Weisser, Juergen [1 ]
Kautz, Armin R. [1 ]
Buechner, Hubert [2 ]
Kuehn, Klaus-Dieter [2 ]
机构：
[1] INNOVENT eV, Biomat Dept, D-07745 Jena, Germany
[2] Heraeus Kulzer GmbH, D-61237 Wehrheim, Germany
来源：
ADVANCED ENGINEERING MATERIALS | 2007年 / 9卷 / 12期
关键词：
D O I：
10.1002/adem.200700223
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
In the current study a new composite material comprising calcium sulphate, calcium carbonate, and tripalmitin was developed as a bioresorbable drug carrier for the local antibiotic therapy. Device fabrication can be simply performed by compression moulding of the components. The evaluated bone substitute material based on a calcium sulphate/calcium carbonate composite exhibits an excellent biocompatibility and a therapeutically useful release profile. It, therefore, represents a promising new antibiotic delivery system for the efficient prevention and treatment of bone infections.
引用
收藏
页码：1135 / 1140
页数：6
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