Use of heated tobacco products, moderate alcohol drinking, and anti-SARS-CoV-2 IgG antibody titers after BNT162b2 vaccination among Japanese healthcare workers

被引：21

作者：

Yamamoto, Shohei ^{[1
,14
]}

Tanaka, Akihito ^{[2
]}

Ohmagari, Norio ^{[3
]}

Yamaguchi, Koushi ^{[4
]}

Ishitsuka, Kazue ^{[5
]}

Morisaki, Naho ^{[5
]}

Kojima, Masayo ^{[6
]}

Nishikimi, Akihiko ^{[7
]}

Tokuda, Haruhiko ^{[8
]}

Inoue, Manami ^{[9
,10
]}

Tanaka, Shiori ^{[9
]}

Umezawa, Jun ^{[9
]}

Okubo, Ryo ^{[11
]}

Nishimura, Kunihiro ^{[12
]}

Konishi, Maki ^{[1
]}

Miyo, Kengo ^{[13
]}

Mizoue, Tetsuya ^{[1
]}

机构：

[1] Natl Ctr Global Hlth & Med, Ctr Clin Sci, Dept Epidemiol & Prevent, Tokyo, Japan

[2] Natl Ctr Global Hlth & Med, Dept Lab Testing, Ctr Hosp, Tokyo, Japan

[3] Natl Ctr Global Hlth & Med, Dis Control & Prevent Ctr, Tokyo, Japan

[4] Natl Ctr Child Hlth & Dev, Ctr Maternal Fetal Neonatal & Reprod Med, Tokyo, Japan

[5] Natl Res Inst Child Hlth & Dev, Dept Social Sci, Tokyo, Japan

[6] Natl Ctr Geriatr & Gerontol, Res Inst, Dept Frailty Res, Obu, Aichi, Japan

[7] Natl Ctr Geriatr & Gerontol, Res Inst, Biosafety Div, Obu, Aichi, Japan

[8] Natl Ctr Geriatr & Gerontol, Res Inst, Bioresource Div, Obu, Aichi, Japan

[9] Natl Canc Ctr Inst Canc Control, Div Prevent, Tokyo, Japan

[10] Natl Canc Ctr, Div Cohort Res, Inst Canc Control, Tokyo, Japan

[11] Natl Ctr Neurol & Psychiat, Clin Res & Educ Promot Div, Tokyo, Japan

[12] Natl Cerebral & Cardiovasc Ctr, Dept Prevent Med & Epidemiol, Osaka, Japan

[13] Natl Ctr Global Hlth & Med, Ctr Med Informat Intelligence, Tokyo, Japan

[14] Natl Ctr Global Hlth & Med, Dept Epidemiol & Prevent, 1-21-1 Toyama,Shinjuku Ku, Tokyo 1628655, Japan

来源：

PREVENTIVE MEDICINE | 2022年 / 161卷

关键词：

Smoking; Heated tobacco products; Alcohol consumption; COVID-19; Vaccine; Immunogenicity; SMOKE;

D O I：

10.1016/j.ypmed.2022.107123

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The effect of heated tobacco products (HTPs) use and moderate alcohol drinking on immunogenicity to coro-navirus disease (COVID-19) vaccines remain elusive. This study aimed to examine the association of tobacco product use and alcohol consumption with anti-SARS-CoV-2 spike IgG antibody titers after the BNT162b2 vaccine. Participants were 3433 healthcare workers receiving two vaccine doses in the 4 national centers for advanced medical and research in Japan. Smoking status and alcohol consumption were assessed via a ques-tionnaire, and anti-SARS-CoV-2 spike IgG titers were measured with chemiluminescent enzyme immunoassay using serum collected on the median of 64 days after the second vaccination. Multilevel linear regression models were used to estimate the geometric mean titers (GMT) and the ratios of means (RoM) between groups with adjustment for covariates. Compared with never-smokers (GMT = 118), IgG antibody titers were significantly lower among HTPs users (including those who also smoked cigarettes) (GMT = 105; RoM = 0.89 [95%CI: 0.78-0.99]) and exclusive cigarettes smokers (GMT = 98; RoM = 0.81 [95%CI: 0.71-0.92]). Compared with non-drinkers of alcohol (GMT = 123), alcohol drinkers consuming < 1 go/day (GMT = 113; RoM = 0.93 [95%CI: 0.88-0.98]), 1-1.9 go/day (GMT = 104; RoM = 0.85 [95%CI: 0.78-0.93]), and >= 2 go/day (GMT = 103; RoM = 0.84 [95%CI: 0.74-0.96]) had significantly lower antibody titers (P for trend < 0.01). Spline analysis showed a large reduction of antibody until around 1 go/day of alcohol consumption, and then they gradually decreased. Results suggest that in addition to conventional cigarette smoking and heavy alcohol drinking, HTPs use and moderate alcohol drinking may be predictors of lower immunological response to COVID-19 vaccine.

引用

页数：6

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