Dynamics of coactivator recruitment and chromatin modifications during nuclear receptor mediated transcription

被引：32

作者：

Aoyagi, Sayura ^{[1
]}

Archer, Trevor K. ^{[1
]}

机构：

[1] Natl Inst Environm Hlth Sci, Chromatin & Gene Express Sect, Mol Carcinogenesis Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2008年 / 280卷 / 1-2期

关键词：

nuclear receptor; transcription; chromatin; coactivator; nucleosome;

D O I：

10.1016/j.mce.2007.08.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mechanisms and interplay of coactivators that underlie transcription activation is a critical avenue of investigation in biology today. Using nuclear receptor (NR) mediated transcription activation as a model, the nature of coactivator recruitment and chromatin modifications has been found to be highly dynamic. Progress in understanding the kinetics and regulation of coactivator recruitment, and subsequent effects on transcriptional readout, has greatly improved our understanding of nuclear receptor mediated transcription, the subject of discussion in this 'At the Cutting Edge' review. Published by Elsevier Ireland Ltd.

引用

页码：1 / 5

页数：5

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