S-nitrosylation of NSF controls membrane trafficking

被引：7

作者：

Söllner, TH ^{[1
]}

Sequeira, S ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Cellular Biochem & Biophys Program, New York, NY 10021 USA

来源：

CELL | 2003年 / 115卷 / 02期

关键词：

D O I：

10.1016/S0092-8674(03)00811-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide is a diffusible molecule with profound effects on regulated exocytosis in several biological systems-however, the molecular targets remain elusive. In this issue of Cell, Matsushita et al. report that in aortic endothelial cells, S-nitrosylation of NSF, an ATPase essential for the activation of the membrane-fusion machinery, inhibits the exocytosis of Weibel-Palade bodies, secretory granules containing a cocktail of mediators essential to the regulation of vascular vesseltone.

引用

页码：127 / 129

页数：3

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