Hepatitis B virus replication is associated with an HBx-Dependent mitochondrion-regulated increase in cytosolic calcium levels

被引：70

作者：

McClain, Stephanie L. ^{[1
]}

Clippinger, Amy J. ^{[1
]}

Lizzano, Rebecca ^{[1
]}

Bouchard, Michael J. ^{[1
]}

机构：

[1] Drexel Univ, Coll Med, Dept Biochem & Mol Biol, Philadelphia, PA 19102 USA

来源：

JOURNAL OF VIROLOGY | 2007年 / 81卷 / 21期

关键词：

D O I：

10.1128/JVI.00740-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nonstructural hepatitis B virus (HBV) protein HBx has an important role in HBV replication and in HBV-associated liver disease. Many activities have been linked to HBx expression; however, the molecular mechanisms underlying many of these activities are unknown. One proposed HBx function is the regulation of cytosolic calcium. We analyzed calcium levels in HepG2 cells that expressed HBx or replicating HBV, and we demonstrated that HBx, expressed in the absence of other HBV proteins or in the context of HBV replication, elevates cytosolic calcium. We linked this elevation of cytosolic calcium to the association of HBx with the mitochondrial permeability transition pore.

引用

页码：12061 / 12065

页数：5

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