Combined effect of dorzolamide and latanoprost on the rate of aqueous humor flow

被引：18
作者：
Vanlandingham, BD
Brubaker, RF
机构：
[1] Mayo Clin & Mayo Fdn, Dept Ophthalmol, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Mayo Med Sch, Rochester, MN 55905 USA
来源：
AMERICAN JOURNAL OF OPHTHALMOLOGY | 1998年 / 126卷 / 02期
关键词：
D O I：
10.1016/S0002-9394(98)00155-X
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
PURPOSE: To determine whether latanoprost, an ocular hypotensive agent believed to enhance uveoscleral outflow of aqueous humor, augments the aqueous-suppressing effect of dorzolamide, a topical carbonic anhydrase inhibitor. METHODS: Twenty-four normal subjects underwent measurement of aqueous humor flow by fluorophotometry to determine the flow with placebo, with dorzolamide, and with a combination of dorzolamide and latanoprost. RESULTS: The flow of aqueous humor was suppressed 13% by dorzolamide but not by latanoprost. Latanoprost did not augment the effect of dorzolamide on aqueous humor flow; latanoprost and dorzolamide had additive ocular hypotensive effects. CONCLUSIONS: The uveoscleral flow effect of latanoprost does not improve the aqueous-suppressing effect of dorzolamide, but the two drugs have additive ocular hypotensive effects. (Am J Ophthalmol 1998;126:191-196. (C) 1998 by Elsevier Science Inc. All rights reserved.).
引用
收藏
页码：191 / 196
页数：6
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